Discovery Early Career Researcher Award - Grant ID: DE170100241
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain dis ....Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This project aims to completely transform the landscape of biomedical research and industry, with expected discoveries revolutionising the diagnosis and treatment of brain conditions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100009
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultrac ....Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultracompact, general-purpose optical conduits into the body through which a wide array of biomedical techniques can be performed in a minimally invasive fashion not currently possible. This project will provide significant benefit to the study of fundamental phenomena in optical fibres.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100010
Funder
Australian Research Council
Funding Amount
$928,291.00
Summary
Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical com ....Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical complexity of traditional tools requiring highly specialised personnel. By offering accessible, easy-to-use advanced systems, this project will significantly boost scientific discovery across physics, chemistry, and biology, fostering collaboration and innovation to better understand life at the molecular level.Read moreRead less
Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to ....Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to afford significant advantages over conventional terahertz imaging platforms. The project plans to explore new semiconductor physics of a quantum cascade laser under optical feedback, engineer the semiconductor laser-based platform for medical diagnostic applications, and develop supporting numerical techniques.Read moreRead less
Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by c ....Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by creating the broad emission spectra through active mode locking in a THz semiconductor laser. The THz laser coupled with the self-detection technique is the key to realising this, and will be explored both in model and experiment.Read moreRead less
Integrated on-chip force and displacement sensors for high-speed atomic force microscopy of ultimate sensitivity. This project aims to develop next generation atomic force microscopy systems based on a novel interferometric method for on-chip force and displacement sensing. The proposed sensitivity improvement of two orders of magnitude over the present state-of-the-art will provide a disruptive innovation for various present and future nanotechnologies.
Towards a unified technology platform for sensing in liquids. Towards a unified technology platform for sensing in liquids. This project aims to use a new sensing platform for hydrocarbon monitoring in water to evolve optical on-chip position sensing of suspended micro-structures. Microelectromechanical systems dominate the world in sensing technology; they are common in smartphone, automotive, aerospace, and military applications. However, this multibillion dollar industry has failed to make ch ....Towards a unified technology platform for sensing in liquids. Towards a unified technology platform for sensing in liquids. This project aims to use a new sensing platform for hydrocarbon monitoring in water to evolve optical on-chip position sensing of suspended micro-structures. Microelectromechanical systems dominate the world in sensing technology; they are common in smartphone, automotive, aerospace, and military applications. However, this multibillion dollar industry has failed to make chem/bio sensing profitable, mostly due to the absence of a robust and compact read-out technology for sensing in liquids. This project is expected to lead to a unified parallel sensing platform of ultimate sensitivity delivering aqueous sensing for wide ranging applications and markets.Read moreRead less
Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, l ....Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, low-cost, single material technology based on silicon-germanium-carbon thin films for mechanical and optical applications from ultraviolet to long-wave infrared, enabling widespread application of spectroscopic imaging to multiple fields extending from climate change research, through resource exploration, to cancer detection, and aerospace/defense.Read moreRead less