The Structural Basis For Promiscuity Of Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$713,035.00
Summary
Special proteins called ion channels control the electrical activity of the heart. Drugs that block ion channels can have the unwanted side-effect of altering the rhythm of the heart beat and causing sudden cardiac death. Extensive efforts are made to screen for this problem during drug development but it is still an inexact science. Here we will use high resolution imaging technologies to get a better understanding of how drugs bind to ion channel proteins.
Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Integrating Attribute Decision Heuristics into Travel Choice Models that accommodate Risk Attitude and Perceptual Conditioning. This proposal has the specific objective of integrating two disconnected literatures that are having a major influence on the behavioural and statistical performance of discrete choice models in travel choice modelling. These fields are attribute processing strategies and the conditioning of the marginal utility of attributes by risk attitude and perceptual conditioning ....Integrating Attribute Decision Heuristics into Travel Choice Models that accommodate Risk Attitude and Perceptual Conditioning. This proposal has the specific objective of integrating two disconnected literatures that are having a major influence on the behavioural and statistical performance of discrete choice models in travel choice modelling. These fields are attribute processing strategies and the conditioning of the marginal utility of attributes by risk attitude and perceptual conditioning. These two major developments have not been jointly integrated into a behaviourally richer representation of choice making. Given the encouraging evidence from both literatures, the research will determine more precisely the benefits in terms of improved estimates of willingness to pay for specific attributes and also increased predictive power. Read moreRead less
Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, a ....Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, and evaluate focussing of waves by complex currents on the continental shelf to help improve wave forecasting in coastal waters. The HF radar will be used to experimentally test current theories of wind wave spreading.Read moreRead less
Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technolo ....Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technological issue identified in the HCS program; and (b) it will enhance Australian manufacturers¡¯ technological standing and input in the design and manufacturing of next generation HCS by providing highly trained people with world-leading niche technology.Read moreRead less
Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcome ....Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcomes are (a) a new constitutive theory for the non-linear behaviour of ferroelectric single crystals; (b) a novel definition and formulation for the shape control problem; and (c) an innovative theoretical framework for design optimization of shape control of smart structures using ferroelectric single crystals.Read moreRead less
Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response wi ....Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response with the transparent electrode design. This project aims to pioneer the application of PLZT optical actuators in morphing flexible structures leading to development of wireless smart structures technology and opt-electromechanical systems such as medical instruments.Read moreRead less
Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that wi ....Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that will have significant impact on the design and maintenance of future rail and road networks. A full understanding of the breakage mechanisms of aggregates will lead to innovative techniques in design and construction, including faster trains carrying heavier loads with reduced maintenance costs.Read moreRead less
Identification Of Heterogeneity In Vasodilator Function In Human And Rat Resistance Vessels: Potential Drug Targets?
Funder
National Health and Medical Research Council
Funding Amount
$595,330.00
Summary
The balance between the ways that blood vessels decrease in size (constrict) and increase in size (dilate) determine how blood vessels normally function. There are many differences in the ways that blood vessels control this balance in different parts of the body. Such differences are altered in vascular diseases, such as hypertension and diabetes, which are prevalent in obesity, such that constriction generally outweighs dilation. However, what these differences are and how they occur are not w ....The balance between the ways that blood vessels decrease in size (constrict) and increase in size (dilate) determine how blood vessels normally function. There are many differences in the ways that blood vessels control this balance in different parts of the body. Such differences are altered in vascular diseases, such as hypertension and diabetes, which are prevalent in obesity, such that constriction generally outweighs dilation. However, what these differences are and how they occur are not well understood. While current drugs for treating vascular disease either reduce vessel constriction or increase dilation, they are not specific for individual arteries; a situation that would allow us to control vascular diseases in a very specific manner. Recently, we have described differences between the ways that individual vessels are controlled. These changes relate to differences in the way that different vessels dilate. AIMS - To further understand normal blood vessel function and the changes that occur in blood vessels in cardiovascular disease, with a focus on the ways that blood vessels dilate in normal states and in obesity-related diseases, such as in hypertension and diabetes. - The eventual aim is to identify the specific ways that arteries function, so that artery-specific drug targets can be identified to treat disease-related changes in cardiovascular disease in a very specific manner. EXPECTED OUTCOMES This project will contribute to understanding blood vessel function in health and disease. The expected eventual outcome is the identification of the mechanisms that underlie the function of different arteries in different parts of the body, so that specific individual vessel function can be targeted to treat vascular disease. Additionally, this work will also verify the relevance of the diet-induced obesity animal model, in terms of the characteristics and causes of human obesity and related cardiovascular disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101793
Funder
Australian Research Council
Funding Amount
$423,038.00
Summary
Quantifying and managing the network impacts of transport sharing services. This project aims to address the challenge of effectively modelling multiple transport sharing services (e.g., ridesharing and parking sharing) in a multimodal network, and efficiently operating these services, and incentivising people to use them. The project expects to generate new knowledge in shared transport by developing an innovative approach to systematically reproducing and optimising network impacts of sharing ....Quantifying and managing the network impacts of transport sharing services. This project aims to address the challenge of effectively modelling multiple transport sharing services (e.g., ridesharing and parking sharing) in a multimodal network, and efficiently operating these services, and incentivising people to use them. The project expects to generate new knowledge in shared transport by developing an innovative approach to systematically reproducing and optimising network impacts of sharing services on travel choices, sharing demand-supply matching patterns, movement trajectory features and traffic dynamics. Expected outcomes include new models and strategies to improve decision support for transport planners and operators. This should provide significant benefits for human mobility and city sustainability.Read moreRead less