Remodelling In Cardiac Hypertrophy: Implications For Arrhythmogenesis
Funder
National Health and Medical Research Council
Funding Amount
$48,361.00
Summary
High blood pressure (HBP) affects 1 in 3 adults. Cardiac hypertrophy (thickened heart muscles) is a common condition seen in HBP. This research seeks to study the underlying changes in electrical, structural and molecular properties of the heart that may contribute to the increased sudden death and atrial fibrillation (irregular heart rhythm) associated with both HBP and cardiac hypertrophy. The new understanding may identify new treatment targets to reduce these life-threatening conditions.
Clinical Features, Neurophysiology And Histopathology Of Peripheral Neuropathy In Children With Mitochondrial Disease
Funder
National Health and Medical Research Council
Funding Amount
$56,200.00
Summary
Peripheral neuropathies are frequently associated with mitochondrial diseases in children and cause progressive weakness and gait abnormalities and could result in loss of ambulation. This study aims to characterise the clinical spectrum and range of electrophysiological and histopathological abnormalities in the peripheral nerves of children with mitochondrial neuropathies to provide a resource that enables early diagnosis and implementation of rehabilitative measures.