Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the p ....Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the protective efficacy of new generation vaccines against M. hyopneumoniae, which aim to block the colonisation process and prevent disease .Read moreRead less
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accu ....Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accurate prediction of the behaviour and lifetime of structural components subject to these fluid-structural interactions, in which the deformation of the structure induced by the local flow field, can in turn influence this flow field. This coupling can result in damage or even catastrophic structural failure and thus robust design tools must be developed to avoid this.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100133
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
National Facility for Physical Blast Simulation (NFPBS). Recent terrorist attacks employing large quantities of high explosives have prompted the international demand for experimental investigation of civil infrastructure response to shock wave loadings. The National Facility for Physical Blast Simulation (NFPBS) is one of only a few in the world that are suitable for conducting experimental research via a physically generated blast approach.
Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally ....Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally efficient engineering models that are accurate and efficient for high speed combustion in rotating detonation engines and scramjets. Expected outcomes are knowledge and tools needed to develop practical and effective supersonic propulsion engines for access to space, defence and high speed point-to-point flight.
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Experimental validation of the strain invariant failure theory for carbon/epoxy composites. The project will be of national and international benefit, through providing a validated, enhanced design capability for advanced composite materials. Greater depth of understanding of such materials will allow more efficient structures to be designed in applications requiring high strength and stiffness, low weight, and resistance to corrosion and fatigue. Such applications include the aerospace, offshor ....Experimental validation of the strain invariant failure theory for carbon/epoxy composites. The project will be of national and international benefit, through providing a validated, enhanced design capability for advanced composite materials. Greater depth of understanding of such materials will allow more efficient structures to be designed in applications requiring high strength and stiffness, low weight, and resistance to corrosion and fatigue. Such applications include the aerospace, offshore and mining industries. There are, therefore, far-reaching benefits in industries important to Australia. In addition, the reputation of the Australian aerospace research industry will be promoted through a collaborative association with Boeing, a world leader in development of commercial aircraft.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100106
Funder
Australian Research Council
Funding Amount
$780,000.00
Summary
A global fireball observatory. This project aims to expand the Desert Fireball Network (DFN) and build a Global Fireball Observatory. Nearly everything known about the origin and evolution of the solar system comes from analysis of meteorite falls, but scientists have almost no constraint on where they come from. This project will address this constraint by tracking hundreds of meteorite falls, and pinpointing each one’s origin in the solar system. Benefits include capitalising on the innovation ....A global fireball observatory. This project aims to expand the Desert Fireball Network (DFN) and build a Global Fireball Observatory. Nearly everything known about the origin and evolution of the solar system comes from analysis of meteorite falls, but scientists have almost no constraint on where they come from. This project will address this constraint by tracking hundreds of meteorite falls, and pinpointing each one’s origin in the solar system. Benefits include capitalising on the innovations and technologies that underpinned the DFN, and leveraging a NASA partnership for administrative support and advanced instrumentation development. Tracking for space situational awareness is also expected to benefit Australian national security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100194
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met th ....Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met through the combined use of state-of-the-art flow visualisation, thermography and spectrometry equipment. These diagnostics would open avenues into so far impossible or difficult to conduct research on highly transient phenomena in various research fields, which include various aspects of fluid mechanics, combustion, and fracture mechanics. The equipment would be instrumental in the design of better and innovative machines, materials, instruments and processes.Read moreRead less
Phytoremediation of arsenic contaminated sites using arsenic hyperaccumulating plants. The legacy of using arsenical compounds in pest control activities has resulted in many contaminated sites. Since the inorganic arsenic is carcinogenic, stringent laws have been enforced to control arsenic (As) in the environment. This project investigates the potential of using the recently discovered (Ma et al, 2001) arsenic hyperaccumulating (22,000 mgAs/kgDW) fern, Pteris vittata, in the removal of arsen ....Phytoremediation of arsenic contaminated sites using arsenic hyperaccumulating plants. The legacy of using arsenical compounds in pest control activities has resulted in many contaminated sites. Since the inorganic arsenic is carcinogenic, stringent laws have been enforced to control arsenic (As) in the environment. This project investigates the potential of using the recently discovered (Ma et al, 2001) arsenic hyperaccumulating (22,000 mgAs/kgDW) fern, Pteris vittata, in the removal of arsenic from dip sites and railway tracks in Qld, and orchards in northern NSW. The impacts of growing hyperaccumulating plants on grazing animals and the environment, and the disposal of arsenic from contaminated plants will also be studied.Read moreRead less