Hydrogel systems for effective encapsulation of functional pancreatic islet cells. This proposal addresses the problem of maintaining viability and function of cells encapsulated within an immuno-isolation barrier material. The research will develop biosynthetic materials that are able to meet design criteria for an effective biomaterial for this application. The major benefits to Australia will be in improved health outcomes by providing safer, more efficacious materials, economic growth develo ....Hydrogel systems for effective encapsulation of functional pancreatic islet cells. This proposal addresses the problem of maintaining viability and function of cells encapsulated within an immuno-isolation barrier material. The research will develop biosynthetic materials that are able to meet design criteria for an effective biomaterial for this application. The major benefits to Australia will be in improved health outcomes by providing safer, more efficacious materials, economic growth development of the Australian Medical Device industry and in high level training of researchers in this field.Read moreRead less
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101530
Funder
Australian Research Council
Funding Amount
$372,744.00
Summary
Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotr ....Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.Read moreRead less
Design and Development of a Low-Cost Portable Biofeedback Device for use in Sleep Induction and Relaxation. This project aims to expand on existing knowledge of the various stimuli used in sleep induction such as photic, auditory and weak electromagnetic stimulation and develop a low-cost portable biofeedback prototype. This novel device will be based on adaptive or fuzzy reasoning algorithms, which would be integrated into the existing ambulatory Siesta EEG recording system, produced by Compume ....Design and Development of a Low-Cost Portable Biofeedback Device for use in Sleep Induction and Relaxation. This project aims to expand on existing knowledge of the various stimuli used in sleep induction such as photic, auditory and weak electromagnetic stimulation and develop a low-cost portable biofeedback prototype. This novel device will be based on adaptive or fuzzy reasoning algorithms, which would be integrated into the existing ambulatory Siesta EEG recording system, produced by Compumedics Ltd. The development of this novel real-time biofeedback prototype will encourage further research using this particular technology to apply it in preventative healthcare in Australian community. The outcome of this proposed bioinstrumentation prototype could possibly expand sleep market to new international level.Read moreRead less
The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the heal ....The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the health and well-being of Australians. The research falls within the Designated National Research Priority of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to the ....Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to therapeutic and economic benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less
OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer ....OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer models. The new technology has great potentials leading to therapeutic and economical benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less