Adolescent Alcohol And Tobacco Use/abuse: The Efficacy Of A Brief Motivational Interviewing And Skills Training Program
Funder
National Health and Medical Research Council
Funding Amount
$153,610.00
Summary
Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health conse ....Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health consequences of heavy drinking and smoking are now well documented. There are many studies exploring the effectiveness of universal prevention programs designed to reduce the chance of alcohol and tobacco problems in high school students. These are associated with short term reductions in the chance of smoking and heavy drinking, however it is unclear whether these programs work for adolescents who are at high risk of alcohol problems and sustained smoking. We know a lot about the sorts of risk factors associated with these problems. They include early onset of use, parental involvement and use, particular personality traits, poor marks, peer use, and poor social skills. There is no research that clearly evaluates prevention programs for adolescents who show these risk factors. In this research, a program tailored for high-risk adolescents will be compared to an educational program similar to what is often received in Australian high schools. It is expected that high-risk students will not show changes in the educational program, but will show long-term improvements after completing the enhanced program. If these results hold, the research will have very important implications for detecting high-risk students and modifying the ways in which these adolescents are treated so that we minimise the chance of further development of alcohol and tobacco problems. This could result in large health cost savings in the future.Read moreRead less
Enhancing Australia's Pandemic Influenza Vaccine Output By Increasing The Yeild Of Vaccine From Eggs
Funder
National Health and Medical Research Council
Funding Amount
$251,517.00
Summary
Influenza epidemics cause significant morbidity and mortality, particularly amongst the young and elderly. Unlike other vaccines, a new flu vaccine formulation needs to be prepared each year from the currently circulating strain. This involves a long process of preparing new seed vaccine stock, which is then tested, manufactured and distributed. The situation is even more complicated by the ability of different influenza strains to reassort with others. An example of current major concern is the ....Influenza epidemics cause significant morbidity and mortality, particularly amongst the young and elderly. Unlike other vaccines, a new flu vaccine formulation needs to be prepared each year from the currently circulating strain. This involves a long process of preparing new seed vaccine stock, which is then tested, manufactured and distributed. The situation is even more complicated by the ability of different influenza strains to reassort with others. An example of current major concern is the possibility of deadly avian flu viruses, such as H5N1, to gain the capacity to directly infect humans by recombining with a human strain and thereby starting a new global pandemic. When the next influenza pandemic occurs, the availability of a vaccine will be of the highest priority and early supply of vaccines will save millions of lives. Since vaccination is the only sustainable defense, we face an urgent need to have the capacity to supply large numbers of vaccine doses of influenza vaccines within a short period of time. Currently, the only way of producing flu vaccines is in eggs. The speed of vaccine supply is totally dependant on the yield of vaccine from eggs and the number of eggs that can be processed at any one time. Since there are severe constraints on the number of eggs that can be simultaneously processed, the limiting factor that can be addressed is the actual yield of vaccine per egg. The aim of this project is the develop methods that allow higher levels of vaccine virus to grow in eggs. We will take a multi-pronged approach to enhancing influenza vaccine production that are directed toward increasing the capacity of eggs to promote virus replication, as well as towards the vaccine strain to boost its ability to replicate in the egg. The outcome will be an enhanced capacity for vaccine manufacturers to quickly and effectively expand vaccine supplies which will directly impact on global morbidity and mortality during a flu pandemic.Read moreRead less
An Investigation Into The Importance Of Potable Water As A Source Of Melioidosis In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$362,036.00
Summary
Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for ....Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for many years before causing late onset infection means that further cases may be recorded in the affected community for years to come. This project aims to assess whether the drinking water supply to other rural communities presents a risk of melioidosis throughout the Top End. Drinking water supplies will be tested for the presence of the bacteria that cause melioidosis. Genetic fingerprinting will be used to compare each strain isolated from water specimens with strains obtained from infections previously diagnosed in hospitals throughout the Top End. This will involve the combined efforts of researchers in Western Australia, the Northern Territory and Queensland. Comparison of these results with standard measures of drinking water quality will enable the research team to work out whether any routinely performed tests can be used as a guide to melioidosis risk. The team will also examine whether any geographical features such as deep water supply or the type of vegetation present can be used to assess melioidosis risk. A clearer picture of melioidosis risk will make it easier to target the delivery of preventive methods such as chlorination or alternatives to specific water supplies. Preliminary studies in Western Australia suggest that primary prevention of melioidosis may be possible. We need to see how widely those findings apply. It is hoped that this work will lead to a significant reduction in the risk of contracting this disease throughout the endemic region.Read moreRead less
The Receptor-associated Protein (RAP) As A Molecular Chaperone For The Amyloid Protein (Abeta) Of Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$402,403.00
Summary
Our research will examine the role of a protein known as the receptor-associated protein (RAP) in Alzheimer's disease. We will determine whether the protein contributes to the progression of Alzheimer's disease and we will examine the possiblity that that RAP may be used as a drug to treat the disease. The project could potentially have direct benefit for patients by leading to an effective treatment for dementia associated with Alzheimer's disease.