Improving Ubiquitous Interventions To Optimise Outcomes From Critical Illness
Funder
National Health and Medical Research Council
Funding Amount
$333,710.00
Summary
A/Prof Deane is a specialist intensive care physician who combines clinical work at The Royal Melbourne Hospital with a large research program. The research supported by this Fellowship will translate to fundamental changes in the administration of ubiquitous interventions and will optimise management of conditions that occur frequently in the critically ill and represent a major source of mortality, morbidity and healthcare utilisation/costs.
Causes And Management Of Abnormally Elevated Blood Glucose Concentrations In The Critically Ill
Funder
National Health and Medical Research Council
Funding Amount
$430,770.00
Summary
Increased glucose concentrations occur commonly in ICU patients and are associated with increased mortality and morbidity. There is a need to improve the understanding of the causes underlying so-called 'critical illness induced hyperglycaemia' as well as new therapies to reduce blood glucose in this group. The proposed studies will focus on the potential role of incretin hormones, which have the capacity to stimulate insulin without increasing the risk of abnormally low blood glucose levels.
Early Regular Egg Exposure During Infancy To Prevent Egg Allergy: A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$2,304,911.00
Summary
Food allergies are common and result in a significant burden to families and the health care system. One approach to prevent food allergies may be to introduce specific foods earlier than currently recommended. The study will compare early regular introduction of egg from 4-6 months compared to the more common practice of egg avoidance until 10 months of age. If successful at reducing egg allergy, this approach will have a significant impact on reducing the burden of allergic disease.
Centre Of Clinical Research Excellence In Nutritional Physiology, Interventions, And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$2,007,200.00
Summary
Over 20% of Australian adults either have diabetes, or are at imminent risk, while 60% are overweight or obese. Conversely, some 40% of the elderly receiving domiciliary support are at risk of malnutrition. Poor nutrition underpins numerous chronic diseases. We seek to capitalise on the expertise and multidisciplinary collaborations of several groups, all leaders in their fields, and whose collective track record in clinical nutrition research cannot be matched in Australia, to form a Centre of ....Over 20% of Australian adults either have diabetes, or are at imminent risk, while 60% are overweight or obese. Conversely, some 40% of the elderly receiving domiciliary support are at risk of malnutrition. Poor nutrition underpins numerous chronic diseases. We seek to capitalise on the expertise and multidisciplinary collaborations of several groups, all leaders in their fields, and whose collective track record in clinical nutrition research cannot be matched in Australia, to form a Centre of Excellence that encompasses the physiology of nutrition, dietary intervention strategies, and evaluation of outcomes, in diabetic, overweight, elderly, and critically unwell populations.Read moreRead less
Promoting Protective Feeding Practices To Prevent Childhood Obesity: Follow Up Of A Successful Obesity Prevention Program Commencing In Infancy.
Funder
National Health and Medical Research Council
Funding Amount
$846,965.00
Summary
Almost one in four Australian children are overweight by the time they start school and at increased risk of becoming overweight adults. This study will evaluate if an intervention to equip parents with the confidence and skills to initiate and maintain positive early feeding practices can foster healthy food preferences, dietary intakes and eating patterns and growth up to five years of age. This is consistent with government focus on early childhood as the foundation for health and well-being.
Upper Gastrointestinal Motor And Absorptive Function In Critically Ill Patients
Funder
National Health and Medical Research Council
Funding Amount
$260,760.00
Summary
A major concern in critically ill patients is the provision of adequate nutrition to facilitate recovery from devastating metabolic insults. Abnormal contractions of the oesophagus, stomach and small intestine appear to be common in critically ill patients. These may prevent effective feeding of patients at a time when they are especially vulnerable to malnutrition and also result in major complications such as pneumonia, septicaemia and gastrointestinal haemorrhage. However little is known abou ....A major concern in critically ill patients is the provision of adequate nutrition to facilitate recovery from devastating metabolic insults. Abnormal contractions of the oesophagus, stomach and small intestine appear to be common in critically ill patients. These may prevent effective feeding of patients at a time when they are especially vulnerable to malnutrition and also result in major complications such as pneumonia, septicaemia and gastrointestinal haemorrhage. However little is known about the reasons underlying these dysfunctions. The applicants, with ongoing support from the NH and MRC have had a longstanding interest in motility disorders of the gut and have made important contributions to knowledge about both the causes and treatments of these conditions. These contributions have been underpinned by pioneering the development of new methodologies to examine gut function. In collaboration with the intensive care specialists in Adelaide, we now seek to apply this knowledge to evaluate gut function in patients in the Intensive Care Unit. The proposed studies will provide the most comprehensive studies to date of the gut function in critically ill patients and have important implications for treatment.Read moreRead less
Mapping The Neural Circuits Involved In Appetite And Feeding Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$404,892.00
Summary
My research project involves deconstructing the neural circuitry underlying feeding behaviour using innovative genetically-based methods. I aim to identify and characterise the major projections of the oxytocin-expressing neurons in the paraventricular hypothalamic nucleus, which have recently been identified as critical in the feeding neurocircuitry. This emerging field of research is predicted to transform our understanding and treatment of disorders such as obesity and anorexia nervosa.