The Role Of Nutrition In Disease-linked Epigenetic Inheritance
Funder
National Health and Medical Research Council
Funding Amount
$485,412.00
Summary
This project aims to investigate one mechanism behind fetal programming, in which a suboptimal in utero environment can affect health of offspring in later life. We and others have recently shown that fetal programming can be caused by changes in the way genes behave, and we will examine how many genes are affected by these changes. We will ask whether the changes can increase in frequency with long-term exposure to nutritional stress, and become entrenched within the population.
Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in ....Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in the Pacific. This knowledge would increase our scientific understanding and enable better predictions of the recurrence of droughts and wet events in Australia.Read moreRead less
How will animals respond to climate change? A genomic approach. This research will identify the genetic basis by which Adélie penguins in Antarctica have been able to respond to a dramatic 10 degree increase in temperature. The research will help us understand the biology of climate adaptation.
Integrating past ice sheet dynamics with palaeoclimate in the Weddell Sea sector to evaluate current and future change in Antarctica. This project will extend historical records of change and understand the complex linkages between Antarctic climate and ice sheet dynamics, thereby assisting in: (i) identifying the mechanisms of past and future ice sheet stability, and (ii) communicating the research outputs to the general public, helping scientific understanding.
Regulation Of Human Arylamine N-acetyltransferase Transcription, Translation And Protein Stability
Funder
National Health and Medical Research Council
Funding Amount
$470,958.00
Summary
Individuals respond very differently to many drugs and other chemicals in the diet and workplace. This variation can be a significant complication in treating patients and in attempting to determine risk with exposure to toxins. Genetic differences between individuals are a common reason for this variation. However, many enzymes and other proteins in humans are controlled by environmental factors that can either increase their activity or inhibit it. In this study, we will investigate how the ac ....Individuals respond very differently to many drugs and other chemicals in the diet and workplace. This variation can be a significant complication in treating patients and in attempting to determine risk with exposure to toxins. Genetic differences between individuals are a common reason for this variation. However, many enzymes and other proteins in humans are controlled by environmental factors that can either increase their activity or inhibit it. In this study, we will investigate how the activity of an important family of enzymes (the acetyltransferases) varies between individuals as a result of environmental factors. We will look at the genes for each of the enzymes and learn about this control mechanism. We will also look careful at the structure of the proteins and determine how this may change when challenged with external stimuli. The expected outcome will be a better understanding of these important enzymes that are involved in the metabolism of many drugs, and also provide a means of determining how different individuals may respond to foreign chemicals and drugs that use these enzymes in the body for metabolism.Read moreRead less
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
Australian Laureate Fellowships - Grant ID: FL100100195
Funder
Australian Research Council
Funding Amount
$2,981,452.00
Summary
Tipping points in Records of Extreme Events in Australasia: Using the Past to Understand and Plan for Abrupt Future Climate Change. This project will generate the fundamental science outputs required to extend historical records of change and understand the complex linkages between Australian and global atmospheric, terrestrial and marine processes in the climate system, thereby assisting in: (i) identifying the mechanisms of past and future climate variability; (ii) developing and validating me ....Tipping points in Records of Extreme Events in Australasia: Using the Past to Understand and Plan for Abrupt Future Climate Change. This project will generate the fundamental science outputs required to extend historical records of change and understand the complex linkages between Australian and global atmospheric, terrestrial and marine processes in the climate system, thereby assisting in: (i) identifying the mechanisms of past and future climate variability; (ii) developing and validating methodologies for improved climate reconstruction and robust chronological frameworks; (iii) predicting the response of Australian ecosystems to future climate change; and (iv) communicating the research outputs to the general public and state, national and international decision makers, helping scientific understanding and aiding resource management.Read moreRead less
Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be tra ....Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be translated into policy. This project aims to understand the health risks associated with heatwaves, to develop health risk-based metrics to define a heatwave across different areas, and to evaluate its implications for the development of social and health policies within an Australian context.Read moreRead less
When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in respons ....When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in response to the major drivers of ice cover and primary productivity. In addition, the major Antarctic POP reservoirs of seawater and ice will be characterised. Empirical data will be used to parameterise a regional fugacity model. Model application to varying climate scenarios will extend our understanding of POP behaviour and threat in polar regions.Read moreRead less
Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes h ....Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes have evolved over the past 100 years. The outcomes will inform debates about the relationship between climatic variability and fire severity, and this will contribute to increase the preparedness of natural resource management to potential future climate and land-use scenarios.Read moreRead less