The Darwin Prospective Melioidosis Study: Years 27-31
Funder
National Health and Medical Research Council
Funding Amount
$1,281,718.00
Summary
The Darwin Prospective Melioidosis Study has documented 914 cases since 1989, with 115 fatalities. A surge in Darwin melioidosis cases over the past 5 years has been linked to urban development and the discovery of a new bacterial strain. Whole genome sequencing of our unique 25+ year set of bacteria and their linked patient data will unravel the changing epidemiology and identify important virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
This study investigates how much an individual's genes and environment account for the wide variation in brain structure and function. Using brain imaging we examine in what way the connectivity of the brain of identical and non-identical twins is the same or different from that of their co-twin, and carry out analysis of their DNA to identify some of the genes involved. This will provide fundamental information on genetic mechanisms influencing variation in brain structure and function.
Discovery Indigenous Researchers Development - Grant ID: DI100100130
Funder
Australian Research Council
Funding Amount
$180,834.00
Summary
Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. ....Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. We will provide management advice on balancing cultural and ecosystem integrity, economic efficiency, and ecosystem resilience under scenarios of climate and environmental change. This information is of immediate use by Australian government agencies. The project will put Australian scientists at the forefront of research focused on the adaptation of marine ecosystems to synergistic effects.Read moreRead less
Nitrogen Removal in Wastewater Treatment Using the Nitrite Pathway. Nitrogen removal from our wastewater is becoming very important in most parts of Australia to protect our unique aquatic environment. This removal is achieved biologically through two steps: Nitrification converts ammonium via nitrite to nitrate; and denitrification converts nitrate via nitrite again to harmless nitrogen gas. This project aims to develop a method that allows this process to go just via nitrite, instead of nitrat ....Nitrogen Removal in Wastewater Treatment Using the Nitrite Pathway. Nitrogen removal from our wastewater is becoming very important in most parts of Australia to protect our unique aquatic environment. This removal is achieved biologically through two steps: Nitrification converts ammonium via nitrite to nitrate; and denitrification converts nitrate via nitrite again to harmless nitrogen gas. This project aims to develop a method that allows this process to go just via nitrite, instead of nitrate, to nitrogen gas. This would significantly reduce oxygen and/or carbon requirement in nitrogen removal. If successful, the new operating method will allow modern wastewater treatment plants to achieve a better effluent quality at lower costs.Read moreRead less
The Aetiology Of Alcohol Use Disorders In Adulthood: A Generational Perspective
Funder
National Health and Medical Research Council
Funding Amount
$630,927.00
Summary
This study aims to investigate the causes of alcohol problems in adult Australians. We will follow-up participants from a birth cohort study who are now in their thirties. We will assess long term outcomes from in-utero exposure to alcohol and biological, developmental and genetic predictors of alcohol disorders in adulthood. This study also aims to study genetic factors which may be important in the development of alcohol abuse and dependence.
How will animals respond to climate change? A genomic approach. This research will identify the genetic basis by which Adélie penguins in Antarctica have been able to respond to a dramatic 10 degree increase in temperature. The research will help us understand the biology of climate adaptation.
When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in respons ....When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in response to the major drivers of ice cover and primary productivity. In addition, the major Antarctic POP reservoirs of seawater and ice will be characterised. Empirical data will be used to parameterise a regional fugacity model. Model application to varying climate scenarios will extend our understanding of POP behaviour and threat in polar regions.Read moreRead less
Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be tra ....Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be translated into policy. This project aims to understand the health risks associated with heatwaves, to develop health risk-based metrics to define a heatwave across different areas, and to evaluate its implications for the development of social and health policies within an Australian context.Read moreRead less
A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding .... A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding the critical exchanges of water and greenhouse gases (GHGs) combining field methodologies and hydrological models, under different climatic conditions. The intended outcomes will benefit management of GHG emissions, coastal flooding and vulnerable groundwater dependent habitats.Read moreRead less