Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100099
Funder
Australian Research Council
Funding Amount
$154,000.00
Summary
Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The propose ....Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The proposed infrastructure is an Australian version of the Automated Self-Administered 24-Hour Dietary Recall (ASA24) in collaboration with the United States National Cancer Institute. The infrastructure is internationally renowned and will underpin research that builds the evidence-base for policies and programs in the field of nutrition and dietetics. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100009
Funder
Australian Research Council
Funding Amount
$3,317,500.00
Summary
ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste ....ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste into valuable materials and products, including metallic alloys, oxides and carbon. Expected outcomes include industry adoption of commercially viable technology and processes where low value or complex waste is reformed into higher value materials, creating jobs and significant environmental and social benefits.Read moreRead less
Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity a ....Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity around the Bay. While dredging and on-land treatment of sediments is being adopted at the most severely contaminated sites, the cost of this approach is exorbitant. For sites where removal of contaminated sediments cannot be justified, the approach proposed in this study of a technology that entraps contaminants and enhances their in situ biodegradation is potentially a way forward.Read moreRead less
Ethics, responsibility and the carbon budget. This project aims to provide a rigorous ethical framework for dividing the world’s remaining ‘carbon budget’ (CB). In order to avoid climate change the world must drastically limit its emissions of greenhouse gases. The project will develop a new analysis of how our assumptions concerning risk and harm shape conception of the CB. It will also provide a new understanding of how future emission rights should be allocated given that countries have emitt ....Ethics, responsibility and the carbon budget. This project aims to provide a rigorous ethical framework for dividing the world’s remaining ‘carbon budget’ (CB). In order to avoid climate change the world must drastically limit its emissions of greenhouse gases. The project will develop a new analysis of how our assumptions concerning risk and harm shape conception of the CB. It will also provide a new understanding of how future emission rights should be allocated given that countries have emitted vastly different quantities of greenhouse gases in the past. The project will analyse how the CB will impact the climate transition plans of countries such as Australia. The project will thus bring significant new research in philosophy to bear on a practical issue.Read moreRead less
Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infi ....Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infiltration, decrease erosion, and off-site transport of P; (ii)increase access to accumulated soil P, making it available to a subsequent potato crop, thus decreasing the P loading of the soil; and (iii) have a biofumigation effect that will reduce the use of soil fumigants.
Read moreRead less
Long range toxic metal pollution in Australia and the Southern Ocean. This project aims to investigate how environmental change and human activities since industrialisation have impacted toxic metal transport and deposition on the south coast of Australia, Tasmania and Southern Ocean islands. This project expects to fill gaps in understanding of the global mercury cycle using a state-of-the-art multidisciplinary methodology including the role of sea salt aerosols and hemispheric-scale wind patte ....Long range toxic metal pollution in Australia and the Southern Ocean. This project aims to investigate how environmental change and human activities since industrialisation have impacted toxic metal transport and deposition on the south coast of Australia, Tasmania and Southern Ocean islands. This project expects to fill gaps in understanding of the global mercury cycle using a state-of-the-art multidisciplinary methodology including the role of sea salt aerosols and hemispheric-scale wind patterns . Anticipated outcomes involve a novel palaeo-atmospheric model that can be applied in other parts of the world. This should provide significant benefits, such as science-based evidence to ratify the Minamata Convention on Mercury and guide new regulations to reduce environmental/health risks from metal pollution.
Read moreRead less
Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in ....Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in decision-making in the event of an oil spill. This project will assess the relative toxicities of a number of petroleum hydrocarbons on Australian seagrass species to provide necessary data for the development of effective management practice.Read moreRead less
Special Research Initiatives - Grant ID: SR0354551
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the ....ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the world's renewable energy industry. An effective structure for networking and for the exchange of people, information and research results will maintain and improve Australia's position in this rapidly growing industry.Read moreRead less
Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-suppo ....Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-support and communication tool to inform the co-design of local climate change mitigation, adaptation and resilience plans. The project aims to give agency to Aboriginal communities in leading a systems change process to reduce environmental risks and strengthen health and wellbeing.Read moreRead less