Iron is essential for brain health. Too little iron can cause problems with memory, concentration and attention and can result in below average intellectual performance or even stroke in children. Too much iron can also be harmful. In the iron overload disease haemochromatosis, iron deposition throughout the body can lead to organ damage in the liver and other tissues. Concentrations of iron in the brain can equal those in liver. Yet surprisingly little is known about the effects of iron on the ....Iron is essential for brain health. Too little iron can cause problems with memory, concentration and attention and can result in below average intellectual performance or even stroke in children. Too much iron can also be harmful. In the iron overload disease haemochromatosis, iron deposition throughout the body can lead to organ damage in the liver and other tissues. Concentrations of iron in the brain can equal those in liver. Yet surprisingly little is known about the effects of iron on the adult human brain. Although the adult brain has traditionally been considered to be protected from the effects of high body iron by the blood-brain barrier, modern techniques show brain iron loading in patients with iron overload disorders or with various brain diseases such as Alzheimer's disease and Parkinson's disease. Several recent studies, including our own, have found associations between mutations in genes important in iron metabolism and brain diseases such as Alzheimer's disease. As many as 30% of Australians have abnormal iron levels (too high or too low) that are often undiagnosed and untreated. There is growing reason to believe these men and women are more likely to have memory problems as well as being at increased risk of brain diseases such as Alzheimer's disease. There is an urgent need for a large-scale study of the short-term and long-term effects of iron levels and related genetic factors on brain health and function. Residents of the Western Australian town of Busselton have participated in a set of health surveys since 1966. We have studied the iron status and related genetic factors in over 3,000 Busselton people. We now propose to perform tests of memory, attention, concentration and related brain activities on the older members of this community group. This will allow us to discover the effects of relevant gene factors, and short- and long-term iron status on memory and other brain functions and on Alzheimer's disease and related disorders.Read moreRead less
Using Epidemiology To Inform Psychiatric Classification (DSM-V And ICD-11)
Funder
National Health and Medical Research Council
Funding Amount
$631,502.00
Summary
Classification systems are vital for scientific progress. The classifications of mental disorders of the World Health Organization and the American Psychiatric Association are both being revised and this Australian team is a principal contributor to both processes. We have access to three national epidemiological surveys (n-30,000) that will inform fundamental issues by developing models of mental disorder typology and identifying practical improvements in the classification systems.
Suicide Ideation, Attempts, Help-seeking Behaviour And Compliance Within The Gold Coast District
Funder
National Health and Medical Research Council
Funding Amount
$111,320.00
Summary
In response to increasing suicide rates in Australia, and abroad, the Australian Government has embraced a nationally coordinated approach to suicide prevention. The National Suicide Prevention Strategy identifies the need for suicide prevention efforts that are based on research evidence. The Australia Institute for Suicide Research and Prevention, in cooperation with the World Health Organisation, is planning to undertake a study to examine suicidal behaviour in the community. Specifically the ....In response to increasing suicide rates in Australia, and abroad, the Australian Government has embraced a nationally coordinated approach to suicide prevention. The National Suicide Prevention Strategy identifies the need for suicide prevention efforts that are based on research evidence. The Australia Institute for Suicide Research and Prevention, in cooperation with the World Health Organisation, is planning to undertake a study to examine suicidal behaviour in the community. Specifically the study will focus on two areas: (a) the willingness of people who displaying suicidal behaviour to seek help and reasons why some people do not seek help, and (b) The compliance with medical treatment among people who seek help following an attempted suicide and the reasons why some of these people do not comply with medical advice. 15,000 people who permanently reside in the Gold Coast Health District will be telephoned at random and asked to participate in the study. Eligible people who agree to participate will be mailed a paper questionnaire. The data gathered in the duty will be examined to gain greater insight into what happens to people following the development or suicidal behaviour. Pilot studies have already revealed that 15% of people in the Gold Coast District have thought about suicide at some time in their lives and as many as 5% have attempted suicide. It is hoped that this study will provide valuable information that can help design more effective suicide prevention programs.Read moreRead less
LONGITUDINAL STUDY OF BEHAVIOUR AND EMOTIONAL PROBLEMS IN YOUNG PEOPLE WITH INTELLECTUAL DISABILITIES
Funder
National Health and Medical Research Council
Funding Amount
$761,790.00
Summary
Families caring for young people with intellectual disabilities face major burdens of care if the young person also has serious behaviour problems. These behaviour problems are also costly for our community. This project is intended to assist young people and their carers by providing new information about the factors contributing to these behaviour problems and how they develop over time. The project makes use of an internationally unique follow up study which has followed a group of young peop ....Families caring for young people with intellectual disabilities face major burdens of care if the young person also has serious behaviour problems. These behaviour problems are also costly for our community. This project is intended to assist young people and their carers by providing new information about the factors contributing to these behaviour problems and how they develop over time. The project makes use of an internationally unique follow up study which has followed a group of young people aged 4-18 for the last eight years. The young people are now entering a critical age band facing many changes in their lives such as the possibility of independent living, work challenges, as well as a search for new social relationships and day activities in the post-school period. Also they face increased risk for mental health problems which most commonly emerge in this age group, particularly psychosis and depression. This project promises to determine how the young people cope with these challenges and what steps our community needs to make to assist them and their families to reach an optimal adjustment.Read moreRead less
Depression And Anxiety In Working Adults: The Costs And Outcomes Of Working While Ill
Funder
National Health and Medical Research Council
Funding Amount
$137,292.00
Summary
Depressive and anxiety disorders are common in the working population and costly. Individuals can continue working while ill or take an absence from work. This study will evaluate the economic cost and health outcomes of these two scenarios, using existing and published data to develop descriptive models. We consider who pays and who benefits from the perspective of the individual, their employer and society, to inform policy making, management practices, and clinical care.