Interplay Of Genetic And Environmental Factors On Age-related Cataract Development
Funder
National Health and Medical Research Council
Funding Amount
$217,519.00
Summary
We aim to investigate factors influencing the development of age-related cataract, using data collected from two population-based studies of older persons: the Blue Mountains Eye Study and the Beaver Dam Eye Study (USA). We will assess genetic susceptibility to the two common forms of age-related cataract, replicated in two Asian samples, and determine how genetic and environmental factors jointly contribute to the development of cataract in some older persons.
Gene-environment Interactions In The Aetiology Of Myopia
Funder
National Health and Medical Research Council
Funding Amount
$671,285.00
Summary
The rapid rise in the prevalence of shortsightedness poses a major public health challenge. The Sydney Myopia Study has collected a large database on environmental risk factors, and has documented a major protective effect of children spending more time outdoors. Other studies suggest that myopia has a major genetic component. This study will collect DNA samples from over 4000 participants in the Sydney Myopia Study, and through genome-wide scanning, will look for gene-environment interactions.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.