Extended Nuclear Deterrence and the Restraint of Non-Nuclear Allies: Material Cooperation and Strategic Dialogue. Extended nuclear deterrence is central to the security commitments offered by the US to its European and Asian allies, but little is known about why non-nuclear allies ask for the nuclear assurances they do and how they influence the assurances they ultimately receive. Using the lenses of intra-alliance bargaining, the role and composition of assurances, and domestic and internationa ....Extended Nuclear Deterrence and the Restraint of Non-Nuclear Allies: Material Cooperation and Strategic Dialogue. Extended nuclear deterrence is central to the security commitments offered by the US to its European and Asian allies, but little is known about why non-nuclear allies ask for the nuclear assurances they do and how they influence the assurances they ultimately receive. Using the lenses of intra-alliance bargaining, the role and composition of assurances, and domestic and international interactions, the project investigates why non-nuclear allies often seek modest extended nuclear deterrence guarantees when they could push for more ambitious commitments. The outcomes of the project will advance theoretical understanding of alliances, assurance and nuclear strategy, with direct relevance to foreign policy and nuclear disarmament.Read moreRead less
Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to prom ....Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to promote a more informed national conversation about the costs and benefits of Australia's security relationship with the United States of America (USA) and contribute to debates over the future of the Australia-USA Alliance during a period of strategic uncertainty.Read moreRead less
Contested multilateralism 2.0 and Asia Pacific security. This project aims to examine the foreign policy choices of five major powers – the United States, China, Japan, South Korea and Australia – toward multilateral institutions in the Asia Pacific after the Cold War through an economic-security-nexus model. Through in-depth theoretical and empirical case studies, this project will explore when states are more likely to rely on rule-based institutions or to use power-based strategies, such as a ....Contested multilateralism 2.0 and Asia Pacific security. This project aims to examine the foreign policy choices of five major powers – the United States, China, Japan, South Korea and Australia – toward multilateral institutions in the Asia Pacific after the Cold War through an economic-security-nexus model. Through in-depth theoretical and empirical case studies, this project will explore when states are more likely to rely on rule-based institutions or to use power-based strategies, such as alliance formation, to pursue security in world politics. This project aims to provide policy insights for Australian policy makers to conduct a sensible and effective “Asia policy” in the 21st century.Read moreRead less
Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-prolifer ....Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-proliferation regime will enable Australian policy-makers to better calibrate the costs and benefits of potential policy changes across these strategic, regime and market realms of Australia's nuclear interests.Read moreRead less
Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection ....Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection mandates on both immediate protection goals and the wider goals of peacekeeping. This project aims to assess the impact of the implementation of mandates to use force to protect civilians. Through a focused comparison of six missions, it plans to identify what works, what doesn't, and the factors which determine these outcomes in order to identify ways of improving performance in the future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100576
Funder
Australian Research Council
Funding Amount
$346,000.00
Summary
Taking sides: Assessing the partiality of international peacekeeping. This project aims to examine an enduring question for peacekeeping: should United Nations peacekeepers take sides between conflict parties, or should they remain impartial brokers that assist combatants to find their own peace settlement? Detailed comparison of six decades of peacekeeping will advance both the theory and practice of peacekeeping by understanding and explaining a striking gap between the long-standing principle ....Taking sides: Assessing the partiality of international peacekeeping. This project aims to examine an enduring question for peacekeeping: should United Nations peacekeepers take sides between conflict parties, or should they remain impartial brokers that assist combatants to find their own peace settlement? Detailed comparison of six decades of peacekeeping will advance both the theory and practice of peacekeeping by understanding and explaining a striking gap between the long-standing principle of impartiality and the frequent, controversial practice of taking sides. By conducting the first systematic study of partiality in peacekeeping and evaluating the effectiveness of this practice, the project aims to contribute new data, theoretical tools and policy proposals for building international peace and stability.Read moreRead less
E-Cadherin Endocytosis In Morphogenesis: Recycling And Growth Factor Induced Uptake.
Funder
National Health and Medical Research Council
Funding Amount
$498,088.00
Summary
E-cadherin is a cell-cell adhesion protein expressed in all epithelia with essential roles in establishing cell polarity and in tissue patterning during development. In the adult, E-cadherin functions to maintain epithelial integrity. E-cadherin is also a vital tumour suppressor, protecting cells against metastatic transformation. Our earlier studies showed that E-cadherin is constantly moved, or trafficked, to and from the surface of epithelial cells. The endocytosis or internalisation of cell ....E-cadherin is a cell-cell adhesion protein expressed in all epithelia with essential roles in establishing cell polarity and in tissue patterning during development. In the adult, E-cadherin functions to maintain epithelial integrity. E-cadherin is also a vital tumour suppressor, protecting cells against metastatic transformation. Our earlier studies showed that E-cadherin is constantly moved, or trafficked, to and from the surface of epithelial cells. The endocytosis or internalisation of cell surface E-cadherin serves to regulate its role in adhesion. More recently, we and others have shown that E-cadherin is endocytosed in response to growth factors, in conjunction with the activated growth factor receptors themselves. E-cadherin can influence the trafficking and signaling of these receptor tyrosine kinases. This joint endocytosis is an elegant mechanism for the simultaneous downregulation of cell adhesion and activation of signaling for cell growth and motility. The growth and differentiation of epithelial cells during tissue patterning or morphogenesis relies critically on these endocytic pathways. Our research is aimed at defining the endosomes and cellular machinery involved in E-cadherin-receptor endocytosis, moreover we will pursue initial findings suggesting that there are different pathways and fates for E-cadherin endocytosed at the behest of different growth factors. We will study endocytosis during the processes of epithelial cyst formation and tubulation of cysts as an in vitro model for mammalian morphogenesis. These studies will provide important and novel information for understanding the roles of E-cadherin in adhesion and in growth factor signaling during epithelial morphogenesis. Ultimately these findings will be of relevance to epithelial development and the prevention of cancer.Read moreRead less
Recycling Endosomes Governing Cell Polarity And Cytokine Secretion.
Funder
National Health and Medical Research Council
Funding Amount
$958,412.00
Summary
Cytokines are chemical messengers released by cells to mount inflammatory responses to fight infections. The timing and direction of cytokine release must be tightly regulated. We investigate the cellular compartments and molecules that control cytokine secretion using sophisticated live cell imaging. Uncontrolled cytokine release is the main cause of ongoing inflammation in arthritis and inflammatory bowel disease and our studies aim to identify cellular targets for new drug development.
Burma's Role in Shaping the Asia-Pacific Strategic Environment. Australia is an active participant in global security affairs, not only as a close ally of the United States but also as an independent middle power with its own perceived sphere of influence. Developments in the strategic environment and the way in which countries attempt to influence state behaviours are central to our national security posture and alliance relationships. Also, the diverse security challenges in the Asia-Pacific r ....Burma's Role in Shaping the Asia-Pacific Strategic Environment. Australia is an active participant in global security affairs, not only as a close ally of the United States but also as an independent middle power with its own perceived sphere of influence. Developments in the strategic environment and the way in which countries attempt to influence state behaviours are central to our national security posture and alliance relationships. Also, the diverse security challenges in the Asia-Pacific region, such as those associated with so-called 'pariah' states like Burma, and the management of related transnational threats, are critical to the formulation and implementation of Australia's foreign and defence policies.
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Paths to primacy: How rising powers win domination in Asia, 1500-present. This Fellowship aims to investigate how, when and why rising powers have historically won regional domination in Asia from 1500CE-present. China today threatens to displace America as Asia’s pre-eminent power. This study will comprehensively examine Asia’s historical geopolitics since 1500, and expects to to produce a new conceptual framework that explains how, when and why rising powers either succeed or fail to seize reg ....Paths to primacy: How rising powers win domination in Asia, 1500-present. This Fellowship aims to investigate how, when and why rising powers have historically won regional domination in Asia from 1500CE-present. China today threatens to displace America as Asia’s pre-eminent power. This study will comprehensively examine Asia’s historical geopolitics since 1500, and expects to to produce a new conceptual framework that explains how, when and why rising powers either succeed or fail to seize regional primacy from their Great Power rivals. The project expects to significantly improve Australia’s historical understanding of the power contests that have made modern Asia, and enhance policymakers’ ability to learn from this history in understanding and responding to modern struggles for regional supremacy.Read moreRead less