Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
The Mechanisms Of Epithelial Cell Survival That Govern Thymus Function
Funder
National Health and Medical Research Council
Funding Amount
$620,967.00
Summary
The thymus is an organ dedicated to the production of crucial immune cells, called T lymphocytes. Cancer treatments, such as radiation or chemotherapy, destroy thymic function and impair immune recovery in patients. We aim to uncover molecular processes that govern the life and death decisions of cells in the thymus. Our goal is to then use this information to develop treatments to protect this critical organ from damage and improve immune recovery following radiation or chemotherapy.
Genetic Programs Orchestrated By AP-1 Transcription Factors In Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$599,941.00
Summary
Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.
Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effe ....Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effective doping and deposition protocols. The expected outcomes of the project include a sovereign primer manufacturing capability for Australia. This will provide a significant strategic advantage and health benefits for law enforcement and defence personnel during live fire training and firing range exercises.Read moreRead less
Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection ....Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection mandates on both immediate protection goals and the wider goals of peacekeeping. This project aims to assess the impact of the implementation of mandates to use force to protect civilians. Through a focused comparison of six missions, it plans to identify what works, what doesn't, and the factors which determine these outcomes in order to identify ways of improving performance in the future.Read moreRead less
Mechanistic Basis Of AP-1-regulated Gene Expression During Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$597,802.00
Summary
The spread of colorectal cancers in the body poses a major clinical problem for which current treatment options are inadequate. This project aims to unravel how a specific DNA-binding protein regulates the expression of genes involved in the spread of these cancers. The research is expected to provide a better mechanistic understanding of how disease progression occurs and to identify novel strategies to treat aggressive tumours.
Immune Modulatory Effects Of Vaginal Microbiota Metabolites And HIV Susceptibility
Funder
National Health and Medical Research Council
Funding Amount
$795,110.00
Summary
This study will advance knowledge on how acid molecules produced by beneficial and harmful bacteria are able to promote or impede HIV infection of the female genital mucosa through their effects on the barrier and immune function of cells that line the vagina and cervix. The results of this study are anticipated to augment the efficacy of topical HIV prevention strategies and lead to the development of safe vaginal hygiene products that help protect against other sexually transmitted infections.
Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distribut ....Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distributed network of nodes can create a detailed picture of the surrounding radio-frequency (RF) environment: the nodes can work together to map the “RF weather”. In this project we will design advanced sensing and localisation methods to accurately map the RF spectrum, and then exploit this map in communication system design.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101094
Funder
Australian Research Council
Funding Amount
$431,900.00
Summary
Energy absorption and impact mechanics of origami structures and materials. This project aims to understand the dynamic behaviour of origami structures and metamaterials by utilising interdisciplinary approaches. This project expects to generate new knowledge in the areas of origami engineering and structural mechanics. The success of this project will form a foundation for studying energy absorption and impact mechanics of origami family; the fundamental physics and mechanics will be applied to ....Energy absorption and impact mechanics of origami structures and materials. This project aims to understand the dynamic behaviour of origami structures and metamaterials by utilising interdisciplinary approaches. This project expects to generate new knowledge in the areas of origami engineering and structural mechanics. The success of this project will form a foundation for studying energy absorption and impact mechanics of origami family; the fundamental physics and mechanics will be applied to characterise microstructures and design novel metamaterials and offer a way of exploring new materials with superior and tuneable performance. This should provide significant benefits to improvement of their safety, stability and reliability performance in applications such as vehicles, warships and offshore engineering.Read moreRead less
Origami structures and materials: energy absorption and impact mechanics. This project will devise novel structures and advanced metamaterials to mitigate injury and death from impact or blast loading, using traditional origami folding concepts of design. This technology will have applications to many industries and occupations including vehicle manufacture and the military, as well as personal and public safety. Experiments and advanced numerical simulations will be performed and then analytica ....Origami structures and materials: energy absorption and impact mechanics. This project will devise novel structures and advanced metamaterials to mitigate injury and death from impact or blast loading, using traditional origami folding concepts of design. This technology will have applications to many industries and occupations including vehicle manufacture and the military, as well as personal and public safety. Experiments and advanced numerical simulations will be performed and then analytical models of structural plasticity and impact dynamics will be established to capture the physics involved. The findings will provide an insight into the fundamental mechanics of structures and metamaterials, as well as guidelines for their optimum design.Read moreRead less