Molecular Profiling Of The Immunoglobulin Proteome In Primary Sjögren’s Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$322,460.00
Summary
Primary Sjögren’s syndrome is a common autoimmune disease. The patients have high levels of circulating immunoglobulins (Igs) in their blood-a hallmark of the disorder. The applicant proposes to sequence these Igs and identify their so-called variable region molecular signatures. These signatures can then be used in a mass spectrometric-based diagnostic platform to identify unique clones in patients as early markers of the disease process, and hopefully lead to more relevant diagnostic markers.
Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the ....Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the assets to be sold on their bidding behaviour and on the seller's revenues. The conduct of laboratory experiments will provide a useful assessment of the theoretical predictions and valuable insights into the effects of buyers' information quality on their bidding behaviour at such markets.Read moreRead less
Identification Of The Conformation Dependant Targets Of Autoimmune Disease Linked Variation In Human Regulatory T Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,001,815.00
Summary
Specialised immune cells called regulatory T cells act as the policemen of the immune system, preventing the immune system attacking itself, but still fighting infections. If these cells do not work properly, autoimmune diseases such as type 1 diabetes or IBD can arise, because of immune attack on normal body tissue by mistake. In order to explain how this goes wrong we need to carefully identify all of the gene interactions in these cells including interactions over long distances in the DNA.
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Price-Setting Rules and Allocative Efficiency in Oligopolies. This project aims to investigate under which circumstances restrictions on how often firms can change prices increase competition in an oligopoly and bring down prices. For this, we propose the use of laboratory experiments with a novel design followed by field experiments and a real price-data analysis for external validation. This study will result in both the advancement of theory describing how firms compete in dynamic oligopolies ....Price-Setting Rules and Allocative Efficiency in Oligopolies. This project aims to investigate under which circumstances restrictions on how often firms can change prices increase competition in an oligopoly and bring down prices. For this, we propose the use of laboratory experiments with a novel design followed by field experiments and a real price-data analysis for external validation. This study will result in both the advancement of theory describing how firms compete in dynamic oligopolies and practical policy advice on how price setting rules can be used to improve consumer welfare. This project has the potential to generate sizable benefits to Australian consumers, as the resulting policy advice would be applicable to large markets such as those for petrol, groceries and online retail.Read moreRead less
Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and pr ....Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and protocols will improve our ability to generate better data and better understand how social and incentive mechanisms can constructively interact to facilitate collaborative environmental action. Results will help make the achievement of environmental targets and the use of public funds more cost-effective. Read moreRead less