Discovery Early Career Researcher Award - Grant ID: DE150101032
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental eco ....Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental economics methods to study how peer presence affects the parameters of the economic decision model, specifically risk tolerance, discounting, and propensity to make errors. The project aims to advance the understanding of decision-making across the lifespan, inform theoretical modelling and advise policy-makers how to reduce the risks to adolescents.Read moreRead less
Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the l ....Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the lab, and assesses the practical significance of the statistical tests used to evaluate laboratory data on mixed-strategy play.Read moreRead less
Communication skills training for oncology health care professionals working with culturally and linguistically diverse patients. The project will develop and evaluate two novel training programs designed to equip health professionals to communicate with cancer patients from different cultures. It is expected that the programs will improve trainees’ ability to communicate in a culturally sensitive way.
Structural and pharmaceutical studies on a novel human protein, MIC-1. Cancer and obesity are two of the main health problems facing Australia, as reflected by the National Research Priority: Promoting and Maintaining Good Health. This project will develop new diagnostic tools for early cancer detection and prognosis using the protein, MIC-1. MIC-1 is responsible for cachexia, a wasting disorder responsible for 25% of cancer deaths, which has no effective therapy. MIC-1 and antibodies neutrali ....Structural and pharmaceutical studies on a novel human protein, MIC-1. Cancer and obesity are two of the main health problems facing Australia, as reflected by the National Research Priority: Promoting and Maintaining Good Health. This project will develop new diagnostic tools for early cancer detection and prognosis using the protein, MIC-1. MIC-1 is responsible for cachexia, a wasting disorder responsible for 25% of cancer deaths, which has no effective therapy. MIC-1 and antibodies neutralising MIC-1 may provide therapeutic agents to control cancer cachexia and severe obesity. The project will optimise these molecules for therapeutic uses. These diagnostic and therapeutic tools will form the basis of a spin-off company for commercialisation. Read moreRead less
Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual huma ....Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual human behaviour. One aim is to deliver hybrid models able to reproduce interesting patterns of first-period play (introspection), time-series data in repeated games (learning), and systematic departures from static equilibrium. Another aim is to apply a successful hybrid to improve the design of economic and social institutions.Read moreRead less
Nobody knows anything? Applying pari-mutuel prediction markets to the motion picture industry. This project will explore the predictability of unreleased motion pictures' theatrical box office revenues using incentive rich pari-mutuel prediction markets. The mechanism will promote price discovery and associated probability estimates that will benefit those already investing in the industry as well as encouraging new investment.
Radiolabelled MMP binding agents for the identification, quantification, and targeting of MMPs in central nervous system (CNS) disorders and tumours. Cancer and diseases of the central nervous system (CNS) represent two of the major health challenges facing Australia because of the aging population. In order to address these challenges we need to develop methods for identifying tumours and CNS diseases using non-invasive technologies and at an early stage so that treatments can be applied when t ....Radiolabelled MMP binding agents for the identification, quantification, and targeting of MMPs in central nervous system (CNS) disorders and tumours. Cancer and diseases of the central nervous system (CNS) represent two of the major health challenges facing Australia because of the aging population. In order to address these challenges we need to develop methods for identifying tumours and CNS diseases using non-invasive technologies and at an early stage so that treatments can be applied when they are most likely to work. In this project, we are developing new radiolabelled compounds that will enable the imaging of tumours, tumour metastases and CNS diseases states.Read moreRead less
New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
The rate of time preference in choice experiments: A systematic re-analysis. This project intends to re-analyse data from over 20 years of past research to understand when and why people sometimes make short-sighted choices. Time preference is a core concept in both theoretical and applied economics and a key input in public policy, yet empirical understanding of it is poor. Almost all important decisions of households, businesses and government involve benefits and costs that unfold over time. ....The rate of time preference in choice experiments: A systematic re-analysis. This project intends to re-analyse data from over 20 years of past research to understand when and why people sometimes make short-sighted choices. Time preference is a core concept in both theoretical and applied economics and a key input in public policy, yet empirical understanding of it is poor. Almost all important decisions of households, businesses and government involve benefits and costs that unfold over time. Many economists have used decision-making experiments to study how people value the future and make trade-offs over time, but these have not reached any clear consensus. This project plans to systematically re-analyse primary data using state-of-the-art estimation techniques to generate new estimates of the discount rate for each study. These will then be analysed in a meta-regression analysis to identify the factors that cause discount rates to vary between studies.Read moreRead less
Translational Research Initiatives In Acute Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Recent research has focussed on molecular characterisation of high-risk acute leukaemia subtypes. This proposal will combine the power of genomic analysis, global analysis of protein kinases and stringent preclinical drug testing in order to improve the treatment of these high-risk acute leukaemia subtypes. Several innovative and interrelated projects within this Program will utilise a unique and clinically relevant experimental model to achieve their goals.