Refining And Testing A Promising New Treatment For Chronic Pain.
Funder
National Health and Medical Research Council
Funding Amount
$743,947.00
Summary
Chronic pain costs Australia about 35 billion dollars a year. Recent scientific discoveries show that treatment aimed at correcting problems in how the brain processes sensory input can reduce pain and disability. This project will clarify some key aspects of these problems and use that information to make final adjustments to an already very promising treatment. We will then test the treatment in a definitive and comprehensive clinical trial.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
THE AUTONOMIC, SOMATIC AND CENTRAL NEURAL RESPONSES TO DEEP AND SUPERFICIAL PAIN IN HUMAN SUBJECTS
Funder
National Health and Medical Research Council
Funding Amount
$375,750.00
Summary
Pain is a subjective experience, the intensity of which can be readily influenced by personal experience. Despite this, pain originating from a particular part of the body will usually be described by all individuals as having similar character. For example, pain arising from the skin is commonly described as being sharp or burning and is usually easy to localise, whereas pain arising from muscle is commonly dull, throbbing and diffuse. In addition to producing sensory changes, pain also evokes ....Pain is a subjective experience, the intensity of which can be readily influenced by personal experience. Despite this, pain originating from a particular part of the body will usually be described by all individuals as having similar character. For example, pain arising from the skin is commonly described as being sharp or burning and is usually easy to localise, whereas pain arising from muscle is commonly dull, throbbing and diffuse. In addition to producing sensory changes, pain also evokes changes in blood pressure, heart rate and motor activity (often in an attempt to remove the source of the pain). The proposed research aims to characterise the cardiovascular and motor patterns associated with pain originating in skin and in muscle and to examine the brain regions that produce these changes. More specifically, microelectrodes will be used to investigate changes in peripheral nerve activity during transient painful skin and muscle events in awake human subjects. In a separate investigation functional magnetic resonance imaging will be used to determine brain sites that are activated by skin or muscle pain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100887
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Economic analysis of time constraints on decision-making in health. This project aims to determine whether and how time constraints affect decision-making. Time constraints can impair the quality of decisions in health, resulting in serious medical and financial consequences. This project will employ experimental economic methods to examine how misaligned preferences and incentives influence decision-making under time constraints. The project will offer scientific evidence and accurate measureme ....Economic analysis of time constraints on decision-making in health. This project aims to determine whether and how time constraints affect decision-making. Time constraints can impair the quality of decisions in health, resulting in serious medical and financial consequences. This project will employ experimental economic methods to examine how misaligned preferences and incentives influence decision-making under time constraints. The project will offer scientific evidence and accurate measurements, provide insights into interventions to align the preferences of doctors and patients, and to lower the overtreatment of patients in the health-care market. The project expects to benefit society and contribute to a more efficient healthcare system.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101032
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental eco ....Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental economics methods to study how peer presence affects the parameters of the economic decision model, specifically risk tolerance, discounting, and propensity to make errors. The project aims to advance the understanding of decision-making across the lifespan, inform theoretical modelling and advise policy-makers how to reduce the risks to adolescents.Read moreRead less
Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the l ....Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the lab, and assesses the practical significance of the statistical tests used to evaluate laboratory data on mixed-strategy play.Read moreRead less
Neuroeconomic foundations of probability and value perception. This project aims to investigate well-known behavioural “biases” in probability and value perception through the lens of neurobiology. This project will generate new knowledge on how the value of rewards, and the likelihood of receiving them, are incorporated in the decision-making process. Using an interdisciplinary approach, this project will be of interest to researchers from several domains of social science, which focus on how a ....Neuroeconomic foundations of probability and value perception. This project aims to investigate well-known behavioural “biases” in probability and value perception through the lens of neurobiology. This project will generate new knowledge on how the value of rewards, and the likelihood of receiving them, are incorporated in the decision-making process. Using an interdisciplinary approach, this project will be of interest to researchers from several domains of social science, which focus on how and why people make their decisions and how we could improve people’s wellbeing by improving their choices. The findings will provide insights into effective, behaviour-related policy design that aims to improve peoples’ well-being.Read moreRead less
Understanding Persistent Low Back Pain Where It Resides, In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$848,972.00
Summary
Low back pain is a leading cause of disability amongst Australians. A critical question is why some people get better after hurting their back while others do not. This project examines whether changes in the brain predict low back pain outcome. This information will rapidly advance our understanding of low back pain and has the potential to facilitate the development of novel therapies.
Neuropathic pain is particularly difficult to treat and existing medications have considerable side effects. This project will develop a new set of glycine transport inhibitors that have the potential to provide pain relief without side effects.
The First Placebo-controlled Trial Of Opioid Analgesics For Acute Spinal Pain
Funder
National Health and Medical Research Council
Funding Amount
$1,024,067.00
Summary
Despite the widespread and increasing use of opioid analgesics, there is a complete lack of evidence on their efficacy in acute spinal pain. Concerns are also being raised because of the risks of potentially serious adverse events associated with opioid analgesics. In this world-first study, we will establish whether using opioid analgesics can effective reduce pain in people with acute spinal pain and provide rigorous evidence to inform the safe and appropriate use of this medicine.