Brm And Brg-1 Protect From Ultraviolet Radiation-induced Skin And Ocular Damage
Funder
National Health and Medical Research Council
Funding Amount
$555,325.00
Summary
Ultraviolet radiation within sunlight is the most important environmental hazard to which Australians are exposed. It causes cancers of the skin and eye, in addition to other forms of skin and eye damage. However sunlight also has health benefits such as vitamin D production. To protect our health from the sun we need to understand how it causes damage and the meachanisms involved. We have discovered a new pathway that we plan to study, called Brm and Brg-1, that provides protection from UV.
Discovery Early Career Researcher Award - Grant ID: DE150101032
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental eco ....Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental economics methods to study how peer presence affects the parameters of the economic decision model, specifically risk tolerance, discounting, and propensity to make errors. The project aims to advance the understanding of decision-making across the lifespan, inform theoretical modelling and advise policy-makers how to reduce the risks to adolescents.Read moreRead less
Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the l ....Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the lab, and assesses the practical significance of the statistical tests used to evaluate laboratory data on mixed-strategy play.Read moreRead less
Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual huma ....Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual human behaviour. One aim is to deliver hybrid models able to reproduce interesting patterns of first-period play (introspection), time-series data in repeated games (learning), and systematic departures from static equilibrium. Another aim is to apply a successful hybrid to improve the design of economic and social institutions.Read moreRead less
Nobody knows anything? Applying pari-mutuel prediction markets to the motion picture industry. This project will explore the predictability of unreleased motion pictures' theatrical box office revenues using incentive rich pari-mutuel prediction markets. The mechanism will promote price discovery and associated probability estimates that will benefit those already investing in the industry as well as encouraging new investment.
The rate of time preference in choice experiments: A systematic re-analysis. This project intends to re-analyse data from over 20 years of past research to understand when and why people sometimes make short-sighted choices. Time preference is a core concept in both theoretical and applied economics and a key input in public policy, yet empirical understanding of it is poor. Almost all important decisions of households, businesses and government involve benefits and costs that unfold over time. ....The rate of time preference in choice experiments: A systematic re-analysis. This project intends to re-analyse data from over 20 years of past research to understand when and why people sometimes make short-sighted choices. Time preference is a core concept in both theoretical and applied economics and a key input in public policy, yet empirical understanding of it is poor. Almost all important decisions of households, businesses and government involve benefits and costs that unfold over time. Many economists have used decision-making experiments to study how people value the future and make trade-offs over time, but these have not reached any clear consensus. This project plans to systematically re-analyse primary data using state-of-the-art estimation techniques to generate new estimates of the discount rate for each study. These will then be analysed in a meta-regression analysis to identify the factors that cause discount rates to vary between studies.Read moreRead less
Translational Research Initiatives In Acute Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Recent research has focussed on molecular characterisation of high-risk acute leukaemia subtypes. This proposal will combine the power of genomic analysis, global analysis of protein kinases and stringent preclinical drug testing in order to improve the treatment of these high-risk acute leukaemia subtypes. Several innovative and interrelated projects within this Program will utilise a unique and clinically relevant experimental model to achieve their goals.
Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to ....Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to develop novel molecular methods for the quantification of Marek's disease viruses (MDV) in the host and the environment, to use these methods to design effective early monitoring systems for MD in broilers that predict disease and performance outcomes, and to develop an epidemiological model that will predict the spread and severity of MD as failure of vaccinal protection progresses.Read moreRead less
The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines ....The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines; (iii) characterise the genetic diversity of strains and; (iv) screen fungicides for the control of these fungi. Information on the species, their biology and pathogenicity on grapevines, will enable the development of appropriate management strategies for its control and may lead to the development of molecular tools to identify species of Botryosphaeria.Read moreRead less
New Approaches to the Control of Post-Weaning Diarrhoea in Piglets. In Australia, post?weaning diarrhoea (PWD) in piglets is a major constraint to efficient and profitable production. Increasing levels of resistance to dietary antibiotics by gut pathogens such as Escherichia coli, the bacterium implicated in PWD, is a major reason for this problem. This research will identify nutritional means of controlling PWD and increasing production after weaning. This will be achieved by strategic nutritio ....New Approaches to the Control of Post-Weaning Diarrhoea in Piglets. In Australia, post?weaning diarrhoea (PWD) in piglets is a major constraint to efficient and profitable production. Increasing levels of resistance to dietary antibiotics by gut pathogens such as Escherichia coli, the bacterium implicated in PWD, is a major reason for this problem. This research will identify nutritional means of controlling PWD and increasing production after weaning. This will be achieved by strategic nutritional interventions in the pre-weaning and (or) post-weaning periods targeted at reducing bacterial pathogens in the gut. A reduction in PWD will increase the overall efficiency of pig production in Australia and reduce antibiotic use.Read moreRead less