The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this resear ....Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this research will have wide implications and applications in biotechnology, genetic engineering, animal breeding, medical science and advanced informatics.Read moreRead less
Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's ec ....Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's economic performance has the potential to impact the well being of individuals and their families, as well as the sustainability of local economies and communities. The project will result in a nuanced understanding of regional employment performance that will inform policy in both government and non-government sectors. Read moreRead less
Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the ....Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the potential to be a significant improvement in the real-time identification of emerging turmoil in financial markets and provide an improved method for the detection of systemic risk. The new test procedure will be implemented using data for financial and non-financial institutions across Europe, the US and Australia.Read moreRead less
An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Austra ....An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Australia to 'age well, age productively' in a national sense. Also, achieving a desired level of national saving is a medium term goal of government economic policy. Hence it is important to understand the interaction of saving, fertility and labour force participation in order to develop compatible and effective economic policies.Read moreRead less
Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of ....Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of a futuristic power system with high penetration of PEDs. The intended outcomes will be a model and data jointly driven methodology for high-efficient and real-time stability assessment. The methodology developed in this project will support Australia's transition to a stable, secure, and low-carbon power grid.Read moreRead less
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
....Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
3) The manpower trained by this project in the areas of multi-scale simulation of MEMS/NEMS/BioMEMS will provide a crucial support for the future industry of Australia.
Read moreRead less
Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPI ....Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPIs)”. This project plans to couple advanced physiological and functional genomics techniques to transform our understanding of how algal symbiont metabolic KPIs regulate coral growth and stress susceptibility. This may provide new diagnostic capability for the assessment of coral health and may enable us to improve coral reef ecosystem management.Read moreRead less