Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Environmental Risk Factors And Genetic Modifiers For Lung Health And Lung Function In A High Risk Cohort
Funder
National Health and Medical Research Council
Funding Amount
$95,348.00
Summary
Asthma is an important determinant of respiratory health and longevity. While early life exposures are thought to be important, the evidence linking them with asthma and lung function is inconclusive. There is a scarcity of longitudinal studies and few investigate genes and environment. This study will determine whether environmental exposures along with their relevant genetic modifiers are related to increased risk of asthma and impaired lung function in a high allergy risk birth cohort.
The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Linking Lifestyle And Molecular Biology To Inform Precision Public Health For Major Cancers
Funder
National Health and Medical Research Council
Funding Amount
$8,487,111.00
Summary
The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based datasets to conduct innovative analyses, improving our understanding of the roles that genetic, epigenetic and lifestyle factors play in our risk of breast, colorectal and prostate cancer. This information should allow us to better predict a person’s cancer risk, enabling public health interventions, such as screening, to be delivered more effectively and e ....The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based datasets to conduct innovative analyses, improving our understanding of the roles that genetic, epigenetic and lifestyle factors play in our risk of breast, colorectal and prostate cancer. This information should allow us to better predict a person’s cancer risk, enabling public health interventions, such as screening, to be delivered more effectively and economically to those most at risk.Read moreRead less
The Role Of Vitamin D In Determining Risk Of Developing Juvenile Idiopathic Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$586,485.00
Summary
Juvenile Idiopathic arthritis (JIA) is an autoimmune disease that occurs in up to 1/250 Australian children. Growing evidence suggests that low vitamin D increases risk of autoimmune disease, yet no-one has looked at its effect on JIA. We will compare vitamin D in blood, and also exposure to sun through life, between children with and without JIA. We will also look to see if vitamin D interacts with autoimmune disease risk genes. The outcomes of this study will help to inform policy on the impor ....Juvenile Idiopathic arthritis (JIA) is an autoimmune disease that occurs in up to 1/250 Australian children. Growing evidence suggests that low vitamin D increases risk of autoimmune disease, yet no-one has looked at its effect on JIA. We will compare vitamin D in blood, and also exposure to sun through life, between children with and without JIA. We will also look to see if vitamin D interacts with autoimmune disease risk genes. The outcomes of this study will help to inform policy on the importance of sun exposure to health.Read moreRead less
Defining An Ethical And Evidence-based Approach To Clinical Research In Children And Adolescents With Chronic Kidney Disease (CKD)
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Chronic kidney disease (CKD) in children and adolescents is a serious health condition, which impacts patients' academic abilities and achievement as well as their social wellbeing and their physical and mental health. This study will investigate the range of impacts that CKD has on patients and families, and explore the ways that these problems should best be addressed in future research from the perspective of patients and their families.