Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Creating Sustainable Healthcare: Ensuring New Diagnostics Avoid Harms, Improve Outcomes, And Direct Resources Wisely
Funder
National Health and Medical Research Council
Funding Amount
$2,497,658.00
Summary
Novel imaging, biomarkers and genomic tests for risk assessment and early detection are emerging as major forces for change in clinical practice. While providing advances and new benefits for patients, new technologies can also have harmful, unintended consequences - overdiagnosis and overtreatment. This multidisciplinary CRE will investigate how to respond to emerging technologies to optimise health outcomes while avoiding harms and directing healthcare resources wisely.
Improving Linkages For Chronic Disease Prevention In Indigenous Communities: A Quality Improvement Approach.
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Primary health care and public health are often conceived as two entities providing complementary services within the health system. This research aims to better understand how to link these complementary services by using quality improvement methods and to identify successful interventions that facilitate these linkages in the prevention of chronic disease in Indigenous communities.
Brm And Brg-1 Protect From Ultraviolet Radiation-induced Skin And Ocular Damage
Funder
National Health and Medical Research Council
Funding Amount
$555,325.00
Summary
Ultraviolet radiation within sunlight is the most important environmental hazard to which Australians are exposed. It causes cancers of the skin and eye, in addition to other forms of skin and eye damage. However sunlight also has health benefits such as vitamin D production. To protect our health from the sun we need to understand how it causes damage and the meachanisms involved. We have discovered a new pathway that we plan to study, called Brm and Brg-1, that provides protection from UV.
Evaluating Cancer Screening: Context, Evidence, Values And Ethics
Funder
National Health and Medical Research Council
Funding Amount
$572,460.00
Summary
The research and clinical communities are divided over whether certain forms of cancer screening do more harm than good. This project asks: What is the right thing to do about cancer screening now? Using robust qualitative methodologies, we will study real cases of cancer screening and analyse their ethical implications. Drawing on this data and analysis, we will produce tools to help policy-makers, consumers and professionals make good decisions about cancer screening in future.
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
Patterns of Buyer Behaviour in China. A mainstream interest of marketers is the study of buyer behaviour (i.e., brand choice, repeat-purchase, switching, loyalty, segmentation, etc.) Much is known. But virtually all of this knowledge comes from Western studies. Yet non-Western nations, such as China, are now immensely important trading partners for the West.
This is the first systematic study of buyer behaviour in China to be based on formal analyses of consumer panel data. An assessment wil ....Patterns of Buyer Behaviour in China. A mainstream interest of marketers is the study of buyer behaviour (i.e., brand choice, repeat-purchase, switching, loyalty, segmentation, etc.) Much is known. But virtually all of this knowledge comes from Western studies. Yet non-Western nations, such as China, are now immensely important trading partners for the West.
This is the first systematic study of buyer behaviour in China to be based on formal analyses of consumer panel data. An assessment will be made of how our analytical models, and associated findings, extend to new conditions (e.g., new geographical markets, sub-regions, traditional Chinese goods, different groups of buyers, etc.).Read moreRead less
Linking Brand Equity Modelling and Measurement with Behavioural and Affective Consumer Decision Processes. Brand equity monitoring often fails to account for image-related and habit-entrenched consumer decision rules. This research takes an established brand equity monitoring tool, A C Nielsen's Winning Brands, and incorporates work on decision heuristics into it. Heuristics occur when consumers simplify their decision task using rules sub-optimal with respect to selecting their preferred alte ....Linking Brand Equity Modelling and Measurement with Behavioural and Affective Consumer Decision Processes. Brand equity monitoring often fails to account for image-related and habit-entrenched consumer decision rules. This research takes an established brand equity monitoring tool, A C Nielsen's Winning Brands, and incorporates work on decision heuristics into it. Heuristics occur when consumers simplify their decision task using rules sub-optimal with respect to selecting their preferred alternative, but effective in terms of reducing cognitive effort. The project will conduct a meta-analysis of over 250 branding strategies followed by a new data collection and latent segmentation analysis. The result will be a more comprehensive decision support tool for brand development, focusing management actions and improving marketing efficiency.Read moreRead less
A cognitive model for identifying optimal measures of beliefs. Belief measures are of high practical relevance. One current national example is measurement of beliefs about recycled water, which will affect state and territory governments' water conservation policies. Another is cultural values, measures of which can form the basis for initiatives to improve social harmony in Australia. The knowledge gained, however, is only as good as the validity of the belief measure employed. We will analyse ....A cognitive model for identifying optimal measures of beliefs. Belief measures are of high practical relevance. One current national example is measurement of beliefs about recycled water, which will affect state and territory governments' water conservation policies. Another is cultural values, measures of which can form the basis for initiatives to improve social harmony in Australia. The knowledge gained, however, is only as good as the validity of the belief measure employed. We will analyse the main types of measures used at present and develop improved belief measures which, when published, will increase the quality of research in the social sciences and enhance Australia's international scientific reputation.Read moreRead less