Epimutations As Germ-line Defects In Hereditary Cancer Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$385,925.00
Summary
Traditionally familial cancers were thought to be caused and inherited by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that a 'chemical coat' around the MLH1 gene, causing it to be switched off, can also be inherited in some cases of bowel cancer, without any mistakes within the gene's code. We will determine if this 'coat' causes other types of cancer and if this runs in families. We also hope to find out how the coat is formed and may be reversed.
Food, drink and sociality in the early Roman Empire and their significance for understanding ancient family and community life. To understand and be secure in the present we must understand the past. The Roman world was multi-cultural and multi-ethnic - a foundation for modern European and Mediterranean cultures. It, therefore, has deep significance for contemporary Australia and its migrant populations. Knowledge of Roman social practices can provide unique insights into issues and dilemmas fac ....Food, drink and sociality in the early Roman Empire and their significance for understanding ancient family and community life. To understand and be secure in the present we must understand the past. The Roman world was multi-cultural and multi-ethnic - a foundation for modern European and Mediterranean cultures. It, therefore, has deep significance for contemporary Australia and its migrant populations. Knowledge of Roman social practices can provide unique insights into issues and dilemmas facing Australian society. Eating behaviours and food practices are of great public interest and understanding the foodways of people in the past is vital to these debates. This project also places Australia at the forefront of archaeological research and guarantees its international prominence in Roman social history.Read moreRead less
Hellenistic Jebel Khalid on the Euphrates,North Syria: the archaeology and history of a Seleucid settlement. Jebel Khalid, a large fortified town guarding a strategic crossing-point on the Euphrates, appears to have been established as a military colony early in the Seleucid period (?=Syrian Amphipolis). Excavation is revealing how far the immigrant Greek/Macedonian colonists settled down to live with the native populations. It is also revealing much about Greek defence systems; about adaptation ....Hellenistic Jebel Khalid on the Euphrates,North Syria: the archaeology and history of a Seleucid settlement. Jebel Khalid, a large fortified town guarding a strategic crossing-point on the Euphrates, appears to have been established as a military colony early in the Seleucid period (?=Syrian Amphipolis). Excavation is revealing how far the immigrant Greek/Macedonian colonists settled down to live with the native populations. It is also revealing much about Greek defence systems; about adaptations of Greek architecture and town-planning (both public and domestic) to local conditions; about civic amenities as well as domestic and religious life; about economic and trading contacts. Important stratigraphic control is also being established over dating Hellenistic pottery, both imported and local wares.Read moreRead less
Discovery Of A Novel Immune Evasion Strategy Employed By Mosquito Borne Viruses To Suppress Antiviral Immune Responses
Funder
National Health and Medical Research Council
Funding Amount
$418,642.00
Summary
The transition from mosquitoes, ticks, or other invertebrate vectors to the human hosts represents a crucial step in the successful establishment of arthropod borne viruses (arboviruses). The incidence of arbovirus infections such as dengue virus, West Nile virus, Ross River virus is increasing at an alarming rate in various parts of the world. In addition, the emergence of new viruses resulting in significant mortality in the population is of utmost concern. Vaccines for many of these viruses r ....The transition from mosquitoes, ticks, or other invertebrate vectors to the human hosts represents a crucial step in the successful establishment of arthropod borne viruses (arboviruses). The incidence of arbovirus infections such as dengue virus, West Nile virus, Ross River virus is increasing at an alarming rate in various parts of the world. In addition, the emergence of new viruses resulting in significant mortality in the population is of utmost concern. Vaccines for many of these viruses remain elusive. One factor that contributes to this is the ability of viruses to develop ingenious strategies to avoid or suppress the host defence systems, which enable its successful establishment in the host. Understanding how viruses evade-suppress host defence machinery will certainly enhance and improve our approaches to fight them. For the first time internationally we have discovered a new and novel pathway employed by arboviruses to suppress antiviral immune responses in the host. We have discovered that naturally occurring carbohydrates on viruses derived from mosquito cells, would influence these virus s ability to evade-suppress host antiviral proteins such as interferons. This may be a general effect of arboviruses or may even extend to other viruses , which include a number of deadly pathogens (HIV, Influenza). This research has the potential to significantly expand our understanding of how these viruses establish infection and cause disease. Also this discovery has broader implications for understanding inflammatory processes and their regulation.Read moreRead less
The archaeology of cultural interaction: The working lives of Greek colonists and indigenous Syrians in Seleucid Syria. The discovery of the unique importance of Jebel Khalid is well known internationally and the project has brought considerable overseas recognition of the contribution of Australian archaeology to Levantine studies. The project fosters research collaboration between Australian and Syrian researchers and institutions and establishes Australia as a major centre for the study of th ....The archaeology of cultural interaction: The working lives of Greek colonists and indigenous Syrians in Seleucid Syria. The discovery of the unique importance of Jebel Khalid is well known internationally and the project has brought considerable overseas recognition of the contribution of Australian archaeology to Levantine studies. The project fosters research collaboration between Australian and Syrian researchers and institutions and establishes Australia as a major centre for the study of the archaeology of Syria. It also fosters goodwill between Australia and an important member of the Arab world and contributes to improving local perceptions of that region.Read moreRead less
Images of Power in the Roman Empire: Mass Media and the Cult of Emperors. Contemporary leaders understand the power of an image to influence public opinion, but are they following a path well-trodden by Roman emperors? This project aims to illuminate the role that mass media and images played in securing and sustaining imperial power during the Later Roman empire from the Flavians to the Theodosians (69-450 CE). The comparison of coins, statues and monuments will shed new light on the dynamic wa ....Images of Power in the Roman Empire: Mass Media and the Cult of Emperors. Contemporary leaders understand the power of an image to influence public opinion, but are they following a path well-trodden by Roman emperors? This project aims to illuminate the role that mass media and images played in securing and sustaining imperial power during the Later Roman empire from the Flavians to the Theodosians (69-450 CE). The comparison of coins, statues and monuments will shed new light on the dynamic ways that popular media were used to mediate between emperors, their officials, provincial elites and the wider populace, and show how leaders used mass media in the Roman world. Social and cultural benefits include a better understanding of the ways that leaders today handle such media to influence public opinion.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100530
Funder
Australian Research Council
Funding Amount
$456,802.00
Summary
Neanderthal hunting ability and the extinction of archaic humans. This project aims to investigate a critical factor in explaining Neanderthals extinction: their hunting abilities. The research expects to generate new knowledge of archaic humans behaviour using an innovative approach combining traditional archaeological analytical methods with ground-breaking biomolecular techniques. Expected outcomes of this project include the development of new knowledge in human evolutionary history and impr ....Neanderthal hunting ability and the extinction of archaic humans. This project aims to investigate a critical factor in explaining Neanderthals extinction: their hunting abilities. The research expects to generate new knowledge of archaic humans behaviour using an innovative approach combining traditional archaeological analytical methods with ground-breaking biomolecular techniques. Expected outcomes of this project include the development of new knowledge in human evolutionary history and improved techniques to understand past human extinction events. This should provide significant benefits for Australia to become a primary power in studying human past and deep history, while enhancing capacity by becoming the first country in the Southern Hemisphere to implement ancient protein studies in archaeology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100464
Funder
Australian Research Council
Funding Amount
$360,724.00
Summary
Conservatism as a dynamic response to the diffusion of innovations. This project aims to investigate how resistance to new and foreign practices and technologies can be a dynamic response to rapid cultural change, rather than a failure to innovate. The project will examine the underlying factors that influence innovation adoption and rejection. It will examine settlement structure and ritual activities in later prehistoric Cornwall, which was simultaneously a key node in the prehistoric economy ....Conservatism as a dynamic response to the diffusion of innovations. This project aims to investigate how resistance to new and foreign practices and technologies can be a dynamic response to rapid cultural change, rather than a failure to innovate. The project will examine the underlying factors that influence innovation adoption and rejection. It will examine settlement structure and ritual activities in later prehistoric Cornwall, which was simultaneously a key node in the prehistoric economy and a periphery, with a distinctly local material culture and way of life. The intended outcome is a model of innovation and conservatism, linking the uptake of new ideas and technologies to participation in local and more widespread networks of contact and exchange. This project will increase the profile of Australian research in archaeology and technology on the world stage.Read moreRead less
Kin and connection: Ancient DNA between the science and the social. This project aims to capitalise on the emerging wealth of ancient DNA data to build bridges between social and scientific archaeologies. It expects to create new knowledge by integrating genetic data with social models of kinship, applying an innovative, cross-disciplinary methodology to the uniquely rich and well-documented archaeological record of prehistoric Europe. Expected outcomes include a new framework for understanding ....Kin and connection: Ancient DNA between the science and the social. This project aims to capitalise on the emerging wealth of ancient DNA data to build bridges between social and scientific archaeologies. It expects to create new knowledge by integrating genetic data with social models of kinship, applying an innovative, cross-disciplinary methodology to the uniquely rich and well-documented archaeological record of prehistoric Europe. Expected outcomes include a new framework for understanding past kinship and the formation of a new interdisciplinary and international research network. Significant benefits include increased value of legacy collections, capacity building in archaeology, and positioning Australia at the forefront of major developments in ancient DNA and archaeological science.Read moreRead less
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less