Mature red cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (Epo). Previously we had identified that the protein Lyn must be present inside primitive red blood cells for Epo to stimulate them to become mature functional cells. We will determine the role of several molecules that interact with Lyn including Cbp, Liar and LACM, towards apects of red blood cell development.
Leukaemia-cancer cells have altered biochemical properties resulting in their high rate of growth compared to normal cells. One of these is augmented activity of enzymes called tyrosine kinases including members of the Src family. One called Lyn has been implicated in several leukaemias as well as cancer. We have identified a novel mechanism of down-regulating this family of enzymes mediated by small proteins. These may allow us to develop novel therapeutics for cancer-leukaemia treatment.
Facilitating the attainment of difficult goals: From theory to intervention. Being persistent in pursuing an important goal is glorified in society. People, however, often need to be strategic in their goal pursuits. A series of lab and field studies will aim to test how helping individuals to realise early in their goal striving whether their goal is attainable or not, can support them in making the right decision (persist with, abandon, or change the goal). The project will make novel contribu ....Facilitating the attainment of difficult goals: From theory to intervention. Being persistent in pursuing an important goal is glorified in society. People, however, often need to be strategic in their goal pursuits. A series of lab and field studies will aim to test how helping individuals to realise early in their goal striving whether their goal is attainable or not, can support them in making the right decision (persist with, abandon, or change the goal). The project will make novel contributions to theories of motivation and goal regulation. It will also have significant public benefit as it will provide the necessary evidence for the development of brief interventions that maximise the efficient use of individuals’ limited resources, facilitating individual and societal productivity and well-being.Read moreRead less
ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. B ....ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. By understanding life course contexts much more finely and using new methods and better data to personalise responses to disadvantage, LCC2020 will deliver the evidence, infrastructure, capacity and partnerships to reduce disadvantage and better equip Australian children and families for emerging challenges. Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100672
Funder
Australian Research Council
Funding Amount
$470,337.00
Summary
Measuring real-time mental workload to improve our Defence capability. This project aims to develop a novel platform for measuring real-time variation in the cognitive workload of humans working with advanced Defence technologies. The project expects to combine innovative statistical techniques with cutting-edge psychological and neuroscience developments to measure and process workload-related brain activity in real-time. Expected outcomes of the project include an enhanced capacity to measure ....Measuring real-time mental workload to improve our Defence capability. This project aims to develop a novel platform for measuring real-time variation in the cognitive workload of humans working with advanced Defence technologies. The project expects to combine innovative statistical techniques with cutting-edge psychological and neuroscience developments to measure and process workload-related brain activity in real-time. Expected outcomes of the project include an enhanced capacity to measure and respond to cognitive workload in the field. This should provide significant benefits such as enhanced performance and safety outcomes, which will provide a strategic advantage to the Australian Defence Force by facilitating the development of advanced technologies that respond to the capabilities of the human user.Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347194
Funder
Australian Research Council
Funding Amount
$411,000.00
Summary
Interactive Television Audience Research Laboratory. Interactive Television is a rapidly emerging platform for global media and e-commerce that is poised to dramatically transform the role of television in society. In collaboration with a range of university and industry partners, Murdoch University aims to establish Australia's first dedicated public research laboratory for assessing consumer motivation, evaluating program usability and theorising audience response to Interactive Television app ....Interactive Television Audience Research Laboratory. Interactive Television is a rapidly emerging platform for global media and e-commerce that is poised to dramatically transform the role of television in society. In collaboration with a range of university and industry partners, Murdoch University aims to establish Australia's first dedicated public research laboratory for assessing consumer motivation, evaluating program usability and theorising audience response to Interactive Television applications. The laboratory will feature specialised testing equipment designed to emulate real-world digital broadcasting environments, enabling rich data on viewing behaviour to be collected and analysed. As an independent facility, the laboratory will provide an invaluable resource for academic and industry research.Read moreRead less
Enhancing outcomes for young people in out-of-home care who self-place. This project aims to enhance the safety and well-being of young people in out-of-home care who leave formal placements to stay in unapproved locations. The significance lies in the development of new knowledge with this group of young people about their needs and of factors shaping effective responses to them. Expected outcomes include the generation of policies and practices to reduce the drivers of young people leaving a ....Enhancing outcomes for young people in out-of-home care who self-place. This project aims to enhance the safety and well-being of young people in out-of-home care who leave formal placements to stay in unapproved locations. The significance lies in the development of new knowledge with this group of young people about their needs and of factors shaping effective responses to them. Expected outcomes include the generation of policies and practices to reduce the drivers of young people leaving approved placements and to address the support and protective needs of young people when staying in unapproved locations. The benefits include improved social and economic inclusion of young people in out-of-home care and reduced socio-economic burdens on health and justice systems associated with placement breakdown. Read moreRead less
Living as a child: children's experiences in England c. 1400-1750. How we best nurture and socialize the next generation of Australians is currently a matter of critical debate. Yet modern Australian attitudes to childhood and practices of child-rearing were first formed in the crucible of pre-modern Europe. Our proposed history of children's experiences in England c. 1400-1750 will provide a rich understanding of the foundations of present-day theories and practices of child-rearing. It will e ....Living as a child: children's experiences in England c. 1400-1750. How we best nurture and socialize the next generation of Australians is currently a matter of critical debate. Yet modern Australian attitudes to childhood and practices of child-rearing were first formed in the crucible of pre-modern Europe. Our proposed history of children's experiences in England c. 1400-1750 will provide a rich understanding of the foundations of present-day theories and practices of child-rearing. It will enable us to distinguish universal features of child-rearing from those which change over time, and to maintain Australia's international reputation for top-class research and research training in pre-modern history and culture.Read moreRead less
Developing Novel Molecules To Down-Regulate Src Family Tyrosine Kinases
Funder
National Health and Medical Research Council
Funding Amount
$201,261.00
Summary
Leukaemia and cancer cells have altered biochemical properties resulting in their high rate of growth compared to normal cells. One of the common biochemical characteristics of cancer-leukaemia cells is augmented activity levels of enzymes called tyrosine kinases. A major group of tyrosine kinase involved in several cancer-leukaemia types is called the Src family of tyrosine kinases. One member of this family called Lyn has been our focus of study for several years, investigating the signalling ....Leukaemia and cancer cells have altered biochemical properties resulting in their high rate of growth compared to normal cells. One of the common biochemical characteristics of cancer-leukaemia cells is augmented activity levels of enzymes called tyrosine kinases. A major group of tyrosine kinase involved in several cancer-leukaemia types is called the Src family of tyrosine kinases. One member of this family called Lyn has been our focus of study for several years, investigating the signalling pathways that it is involved in. This molecule has also been implicated in several specific leukaemia (Chronic Myeloid Leukaemia and Acute Myeloid Leukaemia) as well as cancer (Prostate, Colon, Breast) in recent years. We have identified a novel mechanism of down-regulation of this enzyme mediated by an adapter molecule called Cbp, which recruits the Lyn inactivating molecules Csk-Ctk as well as SOCS-1; together they inhibit the activity of Lyn and degrade the enzyme. Using our knowledge of the essential interaction elements of Cbp we will design and test various mini-Cbp molecules for their ability to inactivate and degrade Lyn in leukemic and cancer cells. These molecules may allow us to develop novel therapeutics capable of inactivating-degrading specific tyrosine kinases in cancer and leukaemia.Read moreRead less