Female Reproductive Health Preservation By Nicotinamide Adenine Dinucleotide (NAD+) And Sirtuin2 (SIRT2)
Funder
National Health and Medical Research Council
Funding Amount
$410,983.00
Summary
Cancer treatment can be severely toxic to women’s eggs. Increasing numbers of women who survive cancer therefore become infertile and prematurely deprived of hormonal support whilst still in their reproductive years. This project will use state-of-the-art techniques to interrogate newly uncovered pathways that can protect eggs from treatment-induced injury thereby greatly improving the quality of life for female cancer survivors.
The Clinicial Centre Of Research Excellence At The Jean Hailes Foundation: For The Study Of Women's Health
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
The major health issues affecting women from the mid-reproductive years include depression, disorders of mood and sexual function, and breast cancer, with cardiovascular disease, osteoporosis, and osteoarthritis becoming increasingly prevalent with age. Linking each of these are their known or probable causal associations with oestrogens and androgens. This Centre will provide an opportunity for comprehensive and multidisciplinary research into the role of oestrogens and androgens in these disor ....The major health issues affecting women from the mid-reproductive years include depression, disorders of mood and sexual function, and breast cancer, with cardiovascular disease, osteoporosis, and osteoarthritis becoming increasingly prevalent with age. Linking each of these are their known or probable causal associations with oestrogens and androgens. This Centre will provide an opportunity for comprehensive and multidisciplinary research into the role of oestrogens and androgens in these disorders.Read moreRead less
Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Mechanisms Of Oxidised Protein Accumulation In Ageing Cells
Funder
National Health and Medical Research Council
Funding Amount
$429,000.00
Summary
Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down ....Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down by the cells and replaced, but in many age-related diseases this process fails. The most common source of protein damage is attack by oxygen-derived free radicals. These are by-products of our body's need for oxygen and can originate from atmospheric pollutants. Oxygen rusts metal, makes fat go rancid and can cause irreparable damage to proteins and other biological molecules. Free radical damage contributes to the development of many age-related diseases such as atherosclerosis and neurodegenerative diseases such as Alzheimer's disease. The accumulation of damaged proteins can cause cell death. Our knowledge of the mechanisms by which cells remove proteins damaged by oxygen and the reasons for their accumulation is limited. In this project we will use a novel technique we have developed to generate oxidised proteins in ageing cells. We will identify cellular mechanisms required for the efficient removal of damaged proteins and those mechanisms which fail in ageing cells. We will focus on a group of proteins which protect damaged proteins from aggregating and accumulating and we will examine how we can prevent the accumulation of oxidised proteins by stimulating the body s defence mechanisms. Since the population of Australia is ageing, diseases of ageing are going to consume an increasing amount of the national health budget. A better knowledge of these cellular mechanisms will allow us to design effective prevention and treatment strategies which are at present lacking.Read moreRead less
Ageing, trust, and financial exploitation: social, emotional and cognitive mechanisms. This project aims to understand how age-related differences in the processing of social and emotional information contribute to the exploitation of older adults' trust. This research will examine deception detection during financial negotiations and provide new strategies for ensuring the financial independence and well-being of older Australians.
Taking advice: Limits and potentials of social decision-making in older age. Older adults are increasingly victims of financial fraud and abuse. While well-intentioned advice has the potential to improve financial decision-making, ill-intentioned advice can lead to exploitation. This project will use extensive behavioural testing to establish the factors governing how much weight older adults give to advice depending on the type of advisor, the type of advice, and feedback about advice quality. ....Taking advice: Limits and potentials of social decision-making in older age. Older adults are increasingly victims of financial fraud and abuse. While well-intentioned advice has the potential to improve financial decision-making, ill-intentioned advice can lead to exploitation. This project will use extensive behavioural testing to establish the factors governing how much weight older adults give to advice depending on the type of advisor, the type of advice, and feedback about advice quality. The outcome will be a model of the influence of advice on decision-making in ageing. This will provide an evidence base to create best practice guidelines, interventions, and decision aids that will reduce exploitation and increase the independence and wellbeing of Australia’s rapidly ageing population.Read moreRead less
Increasing advance personal planning by older adults. This project aims to increase the uptake of advance personal planning among people aged 65 years or over in the community by developing, implementing and evaluating a community action model. People have a legal right to engage in advance personal planning, a process that helps them discuss and document their financial, personal and health preferences, in case they later lose the ability to make or communicate decisions. Few people plan ahead, ....Increasing advance personal planning by older adults. This project aims to increase the uptake of advance personal planning among people aged 65 years or over in the community by developing, implementing and evaluating a community action model. People have a legal right to engage in advance personal planning, a process that helps them discuss and document their financial, personal and health preferences, in case they later lose the ability to make or communicate decisions. Few people plan ahead, even though it can reduce the likelihood of financial exploitation, family conflict and unwanted medical care. This project aims to provide a model of community action to build capacity and collaboration across social services and improve the wellbeing of older people.Read moreRead less
Improving aged care with memory conversations. This project aims to investigate conversational techniques known as "elaborative reminiscing" as a tool for aged care staff to practice relationship-based care in their day-to-day interactions with older clients. The project expects to generate new knowledge about which specific techniques increase reminiscing during routine care, and how these tools have ongoing benefits for aged care clients. Expected outcomes include an evidence-based training pr ....Improving aged care with memory conversations. This project aims to investigate conversational techniques known as "elaborative reminiscing" as a tool for aged care staff to practice relationship-based care in their day-to-day interactions with older clients. The project expects to generate new knowledge about which specific techniques increase reminiscing during routine care, and how these tools have ongoing benefits for aged care clients. Expected outcomes include an evidence-based training program and improved understanding of facilitators and barriers to meeting aged care clients' social needs. This should provide significant benefits by improving wellbeing of clients in aged care, reducing hospitalisations, and enabling aged care providers to meet new industry standards.Read moreRead less
A European DNA Bank For Deciphering The Missing Heritability Of Alzheimer's Disease (EADB)
Funder
National Health and Medical Research Council
Funding Amount
$1,556,995.00
Summary
Understanding the genetics of Alzheimer’s disease (AD) is one of the best ways of improving our knowledge of the underlying mechanisms of disease development. There is evidence that genetic factors account for up to 80% of the risk for AD. Recent advances in genetics still explain <50% of this risk. This proposal will help two major Australian studies to partner with a large European consortium in trying to understand the “missing” heritability, using existing and novel genetic data.
Ageing and self-regulation. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. Our preliminary research suggests that self-regulation may be a significant problem for older Australians. The proposed research will provide a clearer picture of when and why older adults have difficulties regulating their behaviour, and which older adults are particularly susceptible to lapses in self-control. If older adults do hav ....Ageing and self-regulation. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. Our preliminary research suggests that self-regulation may be a significant problem for older Australians. The proposed research will provide a clearer picture of when and why older adults have difficulties regulating their behaviour, and which older adults are particularly susceptible to lapses in self-control. If older adults do have difficulties self-regulating, and if these self-regulation failures incur health, financial and social costs, by gaining a clearer understanding of this problem, the proposed research will take an important step in improving the lives of older Australians. Read moreRead less