Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate impr ....Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate improved technology for early diagnosis of impairment in microvascular flow relevant to muscle insulin resistance and novel therapeutics that improve muscle microvascular blood flow applicable to the treatment of diabetes.Read moreRead less
Blood flow routes in muscle. Ageing well, ageing productively. The Australian population is ageing. The proportion of the population over the age of 65 is expected to greatly increase, reaching 22% by the year 2030. The prevalence of type 2 diabetes in this older population is thought to be ~20%, compared to ~6% in younger populations. An initial cause of type 2 diabetes may be microvascular dysfunction brought on by physical inactivity. Therefore this project addresses the concepts of microvasc ....Blood flow routes in muscle. Ageing well, ageing productively. The Australian population is ageing. The proportion of the population over the age of 65 is expected to greatly increase, reaching 22% by the year 2030. The prevalence of type 2 diabetes in this older population is thought to be ~20%, compared to ~6% in younger populations. An initial cause of type 2 diabetes may be microvascular dysfunction brought on by physical inactivity. Therefore this project addresses the concepts of microvascular function and microvascular fitness by using the latest technology to map blood flow routes in muscle under a number of relevant situations. Read moreRead less
Microdialysis for monitoring changes in microvascular flow patterns in muscle. Microdialysis is a technique for sampling interstitial fluid. Factors altering vascular delivery and removal of nutrients and hormones can affect muscle metabolism by altering exchange with the interstitium. This project focuses on microdialysis for assessing the impact of microvascular blood flow patterns on skeletal muscle metabolism and contractility. The aim is to develop and refine the technology, including equat ....Microdialysis for monitoring changes in microvascular flow patterns in muscle. Microdialysis is a technique for sampling interstitial fluid. Factors altering vascular delivery and removal of nutrients and hormones can affect muscle metabolism by altering exchange with the interstitium. This project focuses on microdialysis for assessing the impact of microvascular blood flow patterns on skeletal muscle metabolism and contractility. The aim is to develop and refine the technology, including equations, specifically for monitoring the nutritive fraction of blood flow in muscle by agents and factors relating to health and disease. This technique could be used for screening drugs in the treatment of diseases such as type 2 diabetes and related conditions.Read moreRead less
Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is int ....Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is intended to prescribe concrete recommendations for the Australian government and aid organizations to assist them in their endeavours to promote democratization and help prevent and/or resolve communal conflict.Read moreRead less
An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised ....An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised through ethnographic studies of mobile work practice, representative use scenarios and the development of an empirically grounded conceptual framework that can guide the design of usable mobile applications.
The results will increase the successful utilisation of mobile technology by Australian industries.
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Judges' work, place and psychological health - a national view. This project aims to address the human, juridical and financial costs of judicial officers’ work-related psychological harm. This harm is implicated in early retirement, sick leave and suicide. It threatens appropriate courtroom conduct, procedural fairness and impartial adjudication. The project seeks to generate new knowledge of the stress judicial officers experience and the individual and institutional mechanisms for managing st ....Judges' work, place and psychological health - a national view. This project aims to address the human, juridical and financial costs of judicial officers’ work-related psychological harm. This harm is implicated in early retirement, sick leave and suicide. It threatens appropriate courtroom conduct, procedural fairness and impartial adjudication. The project seeks to generate new knowledge of the stress judicial officers experience and the individual and institutional mechanisms for managing stressors, combining socio-legal and psychological approaches. Expected outcomes include evidence-based understandings to inform recruitment and retention strategies specific to this highly specialized workforce. This should provide significant benefits for judges’ work capacities and courts' delivery of justice.Read moreRead less
Lifting the Veil on Cold Planets in the Inner Galaxy. The project aims to explore a unique aspect of exoplanet detection: searches for cold planets of Earth mass and larger in the densest stellar fields of the inner Milky Way. Infrared cameras will be used to detect small planets in this extreme galactic environment. The proposed project will open a new era of infrared microlensing observations from the ground and supply critical data in preparation for the next generation of microlensing from s ....Lifting the Veil on Cold Planets in the Inner Galaxy. The project aims to explore a unique aspect of exoplanet detection: searches for cold planets of Earth mass and larger in the densest stellar fields of the inner Milky Way. Infrared cameras will be used to detect small planets in this extreme galactic environment. The proposed project will open a new era of infrared microlensing observations from the ground and supply critical data in preparation for the next generation of microlensing from space. This work directly links to the Nancy Grace Roman Telescope (2026 launch) Galactic Exoplanet Survey. Expected outcomes are a greatly improved understanding of planet formation down to terrestrial-mass planets, and improved techniques for cold planet detection with gravitational microlensing. Read moreRead less
Australia and the OECD: A Neglected Arena in Multi-level Governance. Issues such as trade liberalisation and the development of international agreements are of considerable importance for domestic policy within Australia. Development of such ideas and policies often serve as the basis for subsequent agreements in the multilateral system through policy transfer or the strategy of ?forum shopping?. Australia's interests as a middle power lie in a rules-based system, and thus its ability to maximiz ....Australia and the OECD: A Neglected Arena in Multi-level Governance. Issues such as trade liberalisation and the development of international agreements are of considerable importance for domestic policy within Australia. Development of such ideas and policies often serve as the basis for subsequent agreements in the multilateral system through policy transfer or the strategy of ?forum shopping?. Australia's interests as a middle power lie in a rules-based system, and thus its ability to maximize its effectiveness in shaping those rules is of paramount importance. This project will contribute knowledge which will serve directly this goal, by enhancing our understanding of the OECD as an arena of multilevel governance and Australia's participation within it.Read moreRead less
Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be ....Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be renewed.Read moreRead less
Using jurors to gauge informed public opinion on sentencing. Policy makers and judicial officers are under increasing pressure to respond to public opinion on sentencing issues and yet gauging public opinion on these issues is problematic. This project will use a new means of ascertaining informed public opinion on sentencing issues to better inform policy makers and judicial officers.