Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Information Systems Enabled Corporate Transformation: Evaluation of Electronic Customer Relationship Management in the Service Sector. Customer relationship management (CRM) is a business and marketing strategy that integrates technology, process and business activities around the customer. Only 30% of electronic CRM efforts have been successfully implemented because stakeholder expectations are typically neglected. This issue underlines the importance of the ?soft? organisational issues involve ....Information Systems Enabled Corporate Transformation: Evaluation of Electronic Customer Relationship Management in the Service Sector. Customer relationship management (CRM) is a business and marketing strategy that integrates technology, process and business activities around the customer. Only 30% of electronic CRM efforts have been successfully implemented because stakeholder expectations are typically neglected. This issue underlines the importance of the ?soft? organisational issues involved with the evaluation of information systems. By evaluating the change management process and modelling the impact of e-CRM enabled change, management strategies will be developed to enable its successful implementation. The research will provide a greater understanding for evaluating the performance of e-CRM solutions, as well as uncover opportunities for organisational related change.Read moreRead less
Strategic evaluation model for business-to-business electronic marketplace participation. Striving to become a knowledge-based nation is dependent upon the effective adoption, diffusion and implementation of ICT throughout the business community. The developing world markets, brought about by e-commerce and the increased ability to trade globally facilitated by e-markets, have created significant opportunities for Australian organisations. This research will produce a dynamic model that can be ....Strategic evaluation model for business-to-business electronic marketplace participation. Striving to become a knowledge-based nation is dependent upon the effective adoption, diffusion and implementation of ICT throughout the business community. The developing world markets, brought about by e-commerce and the increased ability to trade globally facilitated by e-markets, have created significant opportunities for Australian organisations. This research will produce a dynamic model that can be used to not only evaluate e-marketplace participation but a wide range of Internet applications. The research will provide Australian managers with the foundation of knowledge needed to guide and support their decision-making when implementing new technology.Read moreRead less
Dynamic Life Cycle Evaluation of Customer Relationship Management Systems. Striving to become a knowledge based nation is dependent upon effective adoption, diffusion and implementation of information and communication technology thoughout the business community. This research will produce a dynamic model that can be used to evaluate enterprise wide applications such as electronic Customer Relationship Management (CRM) so that managers can examine the impact of new tehnology on business processe ....Dynamic Life Cycle Evaluation of Customer Relationship Management Systems. Striving to become a knowledge based nation is dependent upon effective adoption, diffusion and implementation of information and communication technology thoughout the business community. This research will produce a dynamic model that can be used to evaluate enterprise wide applications such as electronic Customer Relationship Management (CRM) so that managers can examine the impact of new tehnology on business processes. In addition, the research will provide managers wit the foundation of knowledge needed to guide and support their decision-making when implementing new technology. Read moreRead less
Classifying the indirect costs of information systems and information technology in business. Many businesses are increasing their expenditure on IS/IT to obtain a strategic competitive advantage. Traditional approaches to IS/IT appraisal are unable to accommodate the costs associated with deploying 'organisational-wide' IS/IT solutions because of their qualitative characteristics. The inability of managers to determine the 'true' costs of IS/IT are attributable to a lack of knowledge and unders ....Classifying the indirect costs of information systems and information technology in business. Many businesses are increasing their expenditure on IS/IT to obtain a strategic competitive advantage. Traditional approaches to IS/IT appraisal are unable to accommodate the costs associated with deploying 'organisational-wide' IS/IT solutions because of their qualitative characteristics. The inability of managers to determine the 'true' costs of IS/IT are attributable to a lack of knowledge and understanding of IS/IT related costs. This research will extend the myopia of traditional 'direct' financial cost analysis by identifying 'indirect' cost factors. A model that integrates cost taxonomies and performance measures/metrics of IS/IT will be developed as a frame of reference for IS/IT decision-makers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454017
Funder
Australian Research Council
Funding Amount
$582,598.00
Summary
A unique Western Australian multi-photon confocal microscope facility to support nationally prioritised biomedical, biological and materials research. Core national priority research will utilise the low dose and penetrative nature of multi-photon confocal microscopy in current research into nerve regeneration after neurotrauma, the histopathological treatment of diabetic retinopathology, and hair cell information transfer processes in auditory physiology. Other programs will study biomineralisa ....A unique Western Australian multi-photon confocal microscope facility to support nationally prioritised biomedical, biological and materials research. Core national priority research will utilise the low dose and penetrative nature of multi-photon confocal microscopy in current research into nerve regeneration after neurotrauma, the histopathological treatment of diabetic retinopathology, and hair cell information transfer processes in auditory physiology. Other programs will study biomineralisation in the superior epithelium of chiton and limpet teeth and a variety of salinity-related plant processes. In parallel, an optical development program will investigate contrast modes in other non-linear interactions. The instrument complements and will be managed with field emission SEM, TEM and a unique high-resolution scanning ion probe in a well-established regional Centre.Read moreRead less
Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platfo ....Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platform for development of a smart data management tool, to oversee the major operational tasks within the plant and help the operators and engineers to make more informed decisions. Direct application of the techniques developed in this study to a pilot case study, could be used as a benchmark to show the potential benefits that can be gained through smart information use and data management.Read moreRead less
Special Research Initiatives - Grant ID: SR0354729
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a h ....Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a higher order of coordination and collaboration in research into ICT applications.
The feasibility study proposed will engage key stakeholders, refine research goals and investigate linkage mechanisms to improve Australia's ICT research and its contribution to economic and social well-being.
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Improving organisational innovation using social media. This project will examine how social media can be effectively used in organisations to improve levels of innovation. The outcomes of the research will put Australia at the forefront of research in the area and have a significant impact on innovation in Australian organisations.