Life-saving chemo/radio-therapy commonly renders women and girls who survivor cancer infertile or sterile. We have discovered a new means of preserving the fertility of female mice exposed to chemo/radio therapy. In this project we will apply these advances to human ovarian tissue/eggs for the first time. We have access to these rare tissues for research purposes. This project will develop new approaches to fertility preservation for cancer survivors.
Preserving Ovarian Function During Chemotherapy And Old Age
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Chemotherapy treatment and the natural ageing process leads to ovarian failure and infertility. For young cancer survivors, chemotherapy induced infertility is devastating, and like aged women, leads to hormonal changes that lead to osteoporosis, diabetes, obesity, and neurodegeneration. Here, a new class of molecules will be tested for their ability to prevent and reverse infertility folllowing chemotherapy treatment, and in old age. These findings will improve the healthy lifespan of women.
Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Austra ....An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Australia to 'age well, age productively' in a national sense. Also, achieving a desired level of national saving is a medium term goal of government economic policy. Hence it is important to understand the interaction of saving, fertility and labour force participation in order to develop compatible and effective economic policies.Read moreRead less
Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can ....Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can better support Australian families with planning and rearing children. A key outcome will be a Parenting Decision-Aid to provide evidence-based reader-friendly information about the positives and negatives of first-time parenthood at different ages.Read moreRead less
Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.
Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of th ....Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of the predictions of the FPC for variable dryland rivers by investigating how food webs in the channels of a floodplain reach respond to flows of different magnitude, seasonal timing and duration.Read moreRead less
Deeper and broader life cycle risk assessment - extending the frontier for hybrid methodologies. This project is about combining detailed and global perspectives of environmental health risk from different fields of planning practice. It aims to improve the depth and breadth of the types of information used by government regulators and the community in decisions about the development of capital works.
Air Pollution And Mortality And Morbidity In Adult Australians (APMMA Study): A Large Population Based Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,041,410.00
Summary
This study will investigate the link between respiratory and cardiovascular disease and mortality and exposure to long-term air pollution. We will use cutting edge methods to assign neighbourhood air pollution levels to a large cohort of NSW adults (n>265,000) previously recruited in the 45 and Up Study. The study results will be of utmost importance in setting outdoor air pollution standards and informing cost benefit analyses of air pollution control strategies.
A cross-national study of the relative impact of an oral component on PhD examination quality, language and practice. High quality doctoral degrees call for the most effective forms of assessment. This project investigates the role of oral examination in PhD assessment, common internationally but not in Australia, and is the first to compare the relative impact of oral and 'no oral' models on examination quality, language and practice.