Leveraging Genomics Strategies To Generate Adult Neurons From IPSCs And Somatic Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,593,336.00
Summary
Recent advances have made it possible to derive myriad specialized human cells from stem cells or by directly reprogramming cell identity. However, these derived cells are generally arrested at a fetal developmental stage, and do not mature to function like adult cells. We will use new genomic, epigenetic, cell reprogramming, and manipulation methods to discover how to derive mature cells, aiming to generate mature neurons for use in neurobiology research, disease modeling, and drug screening.
Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-f ....Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-frequency spectrum and provide scalable bandwidth and wider coverage. Optical wireless transmission is a real alternative to current wireless systems because its connection speed of tens of gigabits/second means it can work efficiently with wired optical networking technologies. This project is expected to lead to optical wireless technology.Read moreRead less
Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100045
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition s ....Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition system for the NASA Gravity Recovery and Climate Experiment follow-on mission; and test-bed development for advanced coherent optical communications systems. Coherent, free-space laser links are an emerging technology for a range of high-impact research fields. The project would enable research relying on precision measurements of time and frequency; advanced inter-satellite laser interferometry, and coherent free-space optical communications. Read moreRead less
Characterization Of Novel Regulators Of Erythropoiesis
Funder
National Health and Medical Research Council
Funding Amount
$437,545.00
Summary
Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature fu ....Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature functional cells. We have identified six molecules which interact with Lyn in red blood cells. We have shown that amolecule called HS1 is important for epo function in individual red blood cells and now we plan to investigate its functions in whole animals, including mice that lack the HS1 gene. We have also shown that a molecule called Trip1 is important for red blood cell development. Interestingly, this molecule also interacts with the thyroid hormone receptor and can influence the effects of epo and thyroid hormone on red blood cell development. The interplay between these two hormones will be looked at in more detail both at the cell and whole animal levels in normal mice and those lacking the thyroid hormone receptor gene. The third Lyn binding molecule we isolated is a novel gene-we have named it ankyrin repeat protein in line with the molecules it is related to. This gene is expressed in red blood cells and we aim to investigate what role it plays in the development of these cells. The fourth gene is also novel and is closely related to another called AFAP-110, which can exert effects on the structure of a cell. Its role in red blood cell structure will also be investigated. Finally, the last two molecule we have identified are both novel and are unrelated to any other known proteins. As above, the effects of these two molecules on red blood cell development will be investigated.Read moreRead less
Creating a national time and frequency network for Australia. This project will develop the means to distribute accurate time and frequency across the Australian continent via an optical fibre network. This network will meet the needs of future telecommunications, science and astronomy projects including the Australian bid for the Square Kilometre Array radio-astronomy project.