Ketamine Therapy Among Patients With Treatment-resistant Depression: A Randomised, Double-blind, Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,069,382.00
Summary
In the last decade, there have been reports of powerful antidepressant effects after a single injection of anaesthetic ketamine, with dramatic (though shortlasting) effects within 24 hours. This will be the first controlled study to test whether a course of repeated ketamine treatments, given over 4 weeks, is effective and safe in treating depression.
Gravity and quantum-limited measurements with a fundamental minimum length. This project aims to investigate the effects of a fundamental minimum length on the nature of gravity and on how accurately we can make measurements in our world. The key challenge is to combine our best theories of fundamental physics to model what happens at ultra-short distances. This project will generate new knowledge at this interface by using a novel approach inspired by information theory. The expected outcomes a ....Gravity and quantum-limited measurements with a fundamental minimum length. This project aims to investigate the effects of a fundamental minimum length on the nature of gravity and on how accurately we can make measurements in our world. The key challenge is to combine our best theories of fundamental physics to model what happens at ultra-short distances. This project will generate new knowledge at this interface by using a novel approach inspired by information theory. The expected outcomes are new connections between fundamental limitations on measurements, the nature of gravitation, and ultra-small-scale quantum physics. The benefit of this work is breaking the logjam in answering the most important open question in all of physics: how to unite quantum theory and gravitation.Read moreRead less
Self-supervised feature learning for rapid processing of marine imagery. Fast and reliable quantitative estimates of marine environmental health are needed for scientific studies, design and management of protected areas, and regulatory compliance of industrial activity in the ocean. Australia is collecting seafloor images at increasing rates but expert annotations are not keeping up, meaning that typical machine learning approaches struggle. This project will develop self-supervised techniques ....Self-supervised feature learning for rapid processing of marine imagery. Fast and reliable quantitative estimates of marine environmental health are needed for scientific studies, design and management of protected areas, and regulatory compliance of industrial activity in the ocean. Australia is collecting seafloor images at increasing rates but expert annotations are not keeping up, meaning that typical machine learning approaches struggle. This project will develop self-supervised techniques that use large amounts of unlabeled data to enhance performance. Our design takes advantage of additional information available for marine imagery such as geolocation and remote sensing context. We will explore how these representations can guide additional sampling and improve performance in classification tasks.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Symbiotic transport proteins in legumes. Some plants form a symbiosis with soil bacteria (rhizobia) that convert atmospheric nitrogen to ammonia which is then supplied to the plant. This enables legumes to grow without application of nitrogen-based fertilizer, avoiding environmental problems such as run-off and land degradation, thereby contributing to sustainable agriculture practise. We will investigate the interactions between plant and rhizobia, focusing on identifying genes and proteins wh ....Symbiotic transport proteins in legumes. Some plants form a symbiosis with soil bacteria (rhizobia) that convert atmospheric nitrogen to ammonia which is then supplied to the plant. This enables legumes to grow without application of nitrogen-based fertilizer, avoiding environmental problems such as run-off and land degradation, thereby contributing to sustainable agriculture practise. We will investigate the interactions between plant and rhizobia, focusing on identifying genes and proteins which govern nutrient exchange between the partners and development of the special structures in the roots that house the bacteria. Subsequent manipulation of these genes and proteins may allow us to identify control points and enhance nitrogen fixation.
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Discovery Early Career Researcher Award - Grant ID: DE120102204
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Quantum computation and relativistic quantum information. Quantum information theory has profound implications both for practical computing and for our fundamental understanding of the universe. This project will determine the viability of one particular quantum computing platform and also develop theoretical and experimental tools to probe the interface between quantum theory and relativity.
Periodontal Disease And Chronic Kidney Disease Among Aboriginal Adults; An RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,035,550.00
Summary
Chronic Kidney Disease is a growing public health concern in Australia, especially among Aboriginal populations. It is associated with progression to end stage kidney disease requiring dialysis, cardiovascular disease burden and high mortality. This study will use a randomised controlled trial design to determine if comprehensive periodontal therapy reduces progression of kidney disease among Aboriginal adults with chronic kidney disease residing in Central Australia.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted u ....Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted use of chemical insecticides. This in turn can produce secondary economic benefits, e.g. through enhanced growth and profitability of the organic beef industry within the main locust-outbreak area. Read moreRead less
Improving Access To Psychological Services For People With Cancer: A Randomised Control Trial Of An Interactive Web-Based Intervention
Funder
National Health and Medical Research Council
Funding Amount
$612,715.00
Summary
Approximately 35% of people diagnosed with cancer will experience persistent significant distress, and unmet psychological supportive care needs in Australian cancer patients are highly prevalent. The web presents a unique method of delivery of supportive care. However, to our knowledge this type of intervention has not been examined. This two-phased study will develop and test a novel web-based intervention to improve psychological outcomes in cancer patients experiencing distress.