Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
A spatio-temporal partitioning approach to colloidal flows in porous media. This project aims to develop an efficient multi-scale laboratory-based modelling framework for colloidal suspensions flow in porous media by utilizing recent advances in 3D/4D image-based geometrical/topological analysis. Regional partitioning techniques based on local structural measures are used to observe the penetration/retention of colloids into identified zones. Zone-dependent colloid interaction probabilities for ....A spatio-temporal partitioning approach to colloidal flows in porous media. This project aims to develop an efficient multi-scale laboratory-based modelling framework for colloidal suspensions flow in porous media by utilizing recent advances in 3D/4D image-based geometrical/topological analysis. Regional partitioning techniques based on local structural measures are used to observe the penetration/retention of colloids into identified zones. Zone-dependent colloid interaction probabilities for computational modelling are derived from fundamental relationships. Expected outcomes of this project include a full-scale modelling capability for heterogeneous samples validated by experiment and the extraction of robust model coefficients for newly developed theory for colloid-suspension transport through porous media.Read moreRead less