Cyclin E1 As A Therapeutic Target In Women With High-grade Serous Cancer And Primary Treatment Failure
Funder
National Health and Medical Research Council
Funding Amount
$644,170.00
Summary
Ovarian cancer is the 5th most common cancer in women and the most lethal gynaecologic malignancy. We found tumours with extra copies of the CyclinE1 gene (CCNE1) are less likely to respond to standard treatment, and show reliance on its activity. Therefore, targeting CCNE1 may be a novel treatment strategy for these cancers. We will perform preclinical studies with therapeutic inhibitors towards the CCNE1 pathway and further explore the underlying biology of tumours with CCNE1 amplification.
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Mechanistic And Functional Drivers Of Neochromosome Evolution
Funder
National Health and Medical Research Council
Funding Amount
$763,771.00
Summary
Neochromosomes are Frankenstein chromosomes--massive extra chromosomes that are stitched together from 100s of pieces of normal chromosomes. They are found in 3% of cancers, but are common in some types, such as liposarcoma. We have mapped their structure and found they form through punctuated chromosome shattering and gene amplification. We will investigate the precise molecular mechanisms that cause this and the recurrent transcriptional and epigenetic drivers lead to their formation.
High Risk Prescribing In Older Australians: Prevalence, Outcomes And Potential For Intervention
Funder
National Health and Medical Research Council
Funding Amount
$595,628.00
Summary
Older people are the most likely to be prescribed medicines yet they are the most likely to be harmed by their medicines. The extent of and trends in high risk prescribing among older Australians are not known. This project will use large-scale linked data to determine the prevalence, risk factors, clinical consequences and costs of high risk prescribing among older people in Australia. The findings of this project will be used to identify targets for minimising harm relating to use of medicines ....Older people are the most likely to be prescribed medicines yet they are the most likely to be harmed by their medicines. The extent of and trends in high risk prescribing among older Australians are not known. This project will use large-scale linked data to determine the prevalence, risk factors, clinical consequences and costs of high risk prescribing among older people in Australia. The findings of this project will be used to identify targets for minimising harm relating to use of medicines.Read moreRead less
High-resolution Brain Imaging Of Cerebellar Non-motor Functions
Funder
National Health and Medical Research Council
Funding Amount
$336,012.00
Summary
This project will develop and apply cutting-edge methods for high resolution, high-field (7 Tesla) functional brain imaging to assess non-motor functions within the cerebellum in the living human brain. This is crucial for understanding and later assessing changes in cerebellar networks and effects of treatment and rehabilitation strategies in a range of cerebellar disorders.
Successful Ageing In Older Men – Thriving Not Just Surviving In The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$628,810.00
Summary
Despite “Ageing well, ageing productively” being listed as a research priority, we still do not know what factors increase the ability for people to live a healthy old age, particularly as they enter their older years. Studies suggest that factors in late life have quite different effects on both survival and the major causes of illness. This application will use a large group of older men who have already been followed for 15 years to determine what increases the chance of successful ageing.
Genetics To Function: Identifying Genes Mediating The Biological Effects Of Type 2 Diabetes GWAS SNPs
Funder
National Health and Medical Research Council
Funding Amount
$438,075.00
Summary
Rates of type 2 diabetes are rising dramatically, and current efforts are failing to stem its progression. More information about why the disease develops is urgently needed. We apply an innovative approach to accelerate the latest genetic discoveries in diabetes to understand the mechanism behind the disease process. This knowledge will lead to new ways to control diabetes through development of novel therapies.
Cellular And Molecular Characterization Of Erythroid Enucleation
Funder
National Health and Medical Research Council
Funding Amount
$671,950.00
Summary
A major challenge for transfusion medicine is the constant difficulties in obtaining enough supply of specific red blood cell (RBC) subtypes. In this proposal, we will identify the key steps of enucleation (extrusion of nucleus), a rate limiting process for the in vitro production of RBCs. A better understanding of this process will lead to improved strategies for the efficient and rapid production of self-generated RBCs for individual patient transfusion.
Antibiotic Tolerance And Small RNA Networks In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$521,559.00
Summary
Treatment of MRSA is restricted to last line antibiotics and treatment failure is associated with an intermediate tolerance to vancomycin. Regulatory molecules termed small RNA mediate responses to antibiotic challenge but their functions are poorly understood. This proposal will profile sRNA function to understand how they adapt S. aureus to antibiotic challenge. A molecular understanding of vancomycin-tolerance will inform development of diagnostics and treatment strategies.
Determining Shared Genetic Control Of RNA Transcription Across 45 Human Tissue Types
Funder
National Health and Medical Research Council
Funding Amount
$264,684.00
Summary
There is strong evidence that much of the genetic susceptibility to disease acts through altering way genes are turned into proteins via RNA transcripts. One important problem in using transcriptomic data to study diseases is that the genetic control of RNA transcription is known to vary between tissues. This study will use new methods and RNA data from 45 human tissues to show the degree of common genetic control for each RNA transcript between each pair of tissues.