Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100235
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
Spectroscopy and imaging platform for photoactive materials. This project aims to establish a comprehensive analytic tool-box to characterise solution-processable materials for thin-film solar cells based on materials such as perovskites. These materials have light harvesting properties with absorption edges beyond 800 nm. This project will focus on time-resolved transient absorption and microwave conductivity phenomena and on lock-in thermographic imaging capabilities. This will accelerate mate ....Spectroscopy and imaging platform for photoactive materials. This project aims to establish a comprehensive analytic tool-box to characterise solution-processable materials for thin-film solar cells based on materials such as perovskites. These materials have light harvesting properties with absorption edges beyond 800 nm. This project will focus on time-resolved transient absorption and microwave conductivity phenomena and on lock-in thermographic imaging capabilities. This will accelerate materials and technological development in this research field. This project is expected to help the local and global energy sector transition to sustainable energy, provide a competitive edge for commercialisations of solar technologies in Australia, and benefit the economy, environment and national security.Read moreRead less
Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international resea ....Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international research effort to determine their structure reliably at the atomic scale. With these new techniques applied to leading compounds and devices, it is expected this project will reveal the structural effects controlling electrical properties and device performance and so enable the design of superior perovskite photovoltaics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101501
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in rese ....Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in research cells to large-area PSCs modules produced through industry-relevant, scalable, and low-cost printing and coating methods. This will provide significant benefits to Australian industry, from small to medium enterprises to larger utility power companies, while creating economic opportunities and enabling sustainable societies.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100005
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub in Zero-emission Power Generation for Carbon Neutrality. This Hub aims to develop sustainable zero-emission power generation technologies to transform gaseous waste (mainly CO2) from our energy and manufacturing sectors into valuable products and create scalable pathways to market for driving industry transformation. This Hub expects to harvest renewable energy from the environment by using zero-emission power generators and then store it in green and safer batteries for convert ....ARC Research Hub in Zero-emission Power Generation for Carbon Neutrality. This Hub aims to develop sustainable zero-emission power generation technologies to transform gaseous waste (mainly CO2) from our energy and manufacturing sectors into valuable products and create scalable pathways to market for driving industry transformation. This Hub expects to harvest renewable energy from the environment by using zero-emission power generators and then store it in green and safer batteries for converting gaseous waste from sectors that cannot easily avoid emission into useful chemicals, which in turn realize carbon neutrality and negativity. The outcomes of this Hub are likely to be transformative for industry, the economy, and society in new-type renewable energy resources through decreasing environmental pollutants. Read moreRead less
Wearable thermoelectric textiles for portable microelectronics. Wearable thermoelectrics enable the power generation from the temperature difference between human body and ambient temperature by using thermoelectric effect. This project aims to design eco-friendly wearable thermoelectric textiles to realize high-efficiency solid-state power generation and meet individual needs with human comfort and health. The target is to achieve a power density in the as-designed thermoelectric textiles by th ....Wearable thermoelectric textiles for portable microelectronics. Wearable thermoelectrics enable the power generation from the temperature difference between human body and ambient temperature by using thermoelectric effect. This project aims to design eco-friendly wearable thermoelectric textiles to realize high-efficiency solid-state power generation and meet individual needs with human comfort and health. The target is to achieve a power density in the as-designed thermoelectric textiles by the optimization of materials and device design. The outcome will open up a new platform for the green and sustainable charge for portable microelectronics, which will lead to an innovative technology for energy management, which will place Australia at the forefront of wearable electronics and textile industry.Read moreRead less