Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem d ....Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem device. The expected outcome is a solar cell that can convert more than 30 per cent of incident sunlight into electricity, compared to 20-25 per cent for current cells. Developing cheap, high efficiency solar cells should further reduce the cost of solar electricity, and accelerate the uptake of clean energy.Read moreRead less
Understanding The Role Of The Putative Phospholipid Translocase ATP11c In B Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$455,153.00
Summary
The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.
Doped metal perovskites for electrocatalysis. This project aims to discover and design perovskite metal-oxide electrocatalyst materials and develop electrocatalytic methods for efficiently driving the oxygen evolution reaction and the oxygen reduction reaction. These are the two most crucial reactions in sustainable energy cycles involving water, hydrogen and oxygen. The project’s anticipated advances in electrocatalysis efficiency for these two reactions will benefit sustainable energy technolo ....Doped metal perovskites for electrocatalysis. This project aims to discover and design perovskite metal-oxide electrocatalyst materials and develop electrocatalytic methods for efficiently driving the oxygen evolution reaction and the oxygen reduction reaction. These are the two most crucial reactions in sustainable energy cycles involving water, hydrogen and oxygen. The project’s anticipated advances in electrocatalysis efficiency for these two reactions will benefit sustainable energy technologies such as fuel cells, metal air batteries and water splitting.Read moreRead less
Stable perovskite-unlocking the full potential of low-cost solar cells. Despite impressive conversion efficiency, the perovskites' poor stability impedes their commercialization. This project aims to develop strategies for stable perovskite solar cells. This will be realized by a thorough understanding of the degradation origins with stimuli, and development of degradation mitigation strategies including materials and interfaces engineering, defect control and passivation, synergized by a system ....Stable perovskite-unlocking the full potential of low-cost solar cells. Despite impressive conversion efficiency, the perovskites' poor stability impedes their commercialization. This project aims to develop strategies for stable perovskite solar cells. This will be realized by a thorough understanding of the degradation origins with stimuli, and development of degradation mitigation strategies including materials and interfaces engineering, defect control and passivation, synergized by a systematic degradation evaluation, state-of-art multi-scale material and device characterizations and device modeling providing feedback for optimization. The project will bring new scientific findings, key technological step-change solutions, unlocking the full potential of perovskites for cheaper photovoltaic technologies.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100235
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
Spectroscopy and imaging platform for photoactive materials. This project aims to establish a comprehensive analytic tool-box to characterise solution-processable materials for thin-film solar cells based on materials such as perovskites. These materials have light harvesting properties with absorption edges beyond 800 nm. This project will focus on time-resolved transient absorption and microwave conductivity phenomena and on lock-in thermographic imaging capabilities. This will accelerate mate ....Spectroscopy and imaging platform for photoactive materials. This project aims to establish a comprehensive analytic tool-box to characterise solution-processable materials for thin-film solar cells based on materials such as perovskites. These materials have light harvesting properties with absorption edges beyond 800 nm. This project will focus on time-resolved transient absorption and microwave conductivity phenomena and on lock-in thermographic imaging capabilities. This will accelerate materials and technological development in this research field. This project is expected to help the local and global energy sector transition to sustainable energy, provide a competitive edge for commercialisations of solar technologies in Australia, and benefit the economy, environment and national security.Read moreRead less