Preclinical Development Of TLR Signalling Inhibitors For Prevention Of Preterm Labour And Fetal Inflammatory Injury
Funder
National Health and Medical Research Council
Funding Amount
$690,821.00
Summary
Preterm birth affects 8% of Australian births and is a major cause of infant and child health problems. Therapies to prevent or delay prematurity are urgently required. This study will investigate new drugs that suppress the triggers of preterm labour. We will evaluate drug effects in mice and human placental tissue, to demonstrate safety and fetal protection from inflammatory injury that occurs with prematurity. Successful completion of the study is expected to lead to clinical trials in women.
Understanding How GATA2 Controls Lymphatic Vessel Valve Development
Funder
National Health and Medical Research Council
Funding Amount
$697,942.00
Summary
Mutations in the GATA2 gene cause human lymphoedema as a result of the crucial role that GATA2 plays in controlling the expression of genes important for building functional lymphatic vessels. Here we aim to gain a complete picture of the cellular and molecular events that are controlled by GATA2 in lymphatic vessels and in particular, in lymphatic vessel valves.
Nanostructured non-precious metal and metal-free catalysts for sustainable clean energy generation. The innovative technologies for substitution of precious metal catalysts will be developed and used in fuel cells for clean energy generation in a highly efficient and sustainable form. This effort will lead to the reduction in carbon dioxide emissions and the alleviation of environmental and climate change problems.
Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocata ....Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocatalysis: the reactivity of active sites and the catalytic performance with the number of active sites; which will not only significantly advance knowledge but also achieve breakthrough technologies that greatly benefit to the society and economy both for Australia and worldwide.Read moreRead less
Pregnancy And Neonatal Diabetes Outcomes In Remote Australia (PANDORA) Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,395,410.00
Summary
The PANDORA study is a longitudinal birth cohort study recruited from a clinical register of Northern Territory women with diabetes in pregnancy (DIP). We will also recruit a comparator group of mothers without DIP and babies. Follow-up of mothers and infants to 3 years post-delivery will be from medical records, questionnaires and clinical assessment. Rates of progression to type 2 diabetes will be assessed among mothers, and growth, feeding patterns and diabetes risk markers among infants.
Characterising Signals Important For Lymphangiogenesis During Development And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$604,938.00
Summary
Lymphatic vessels are a vital component of the cardiovascular system. Abnormalities in the growth and development of lymphatic vessels are associated with human disorders including cancer, lymphoedema and inflammatory diseases. The focus of this application is to characterise signals that direct the construction of lymphatic vessels, with the aim of identifying targets to which novel therapeutics for the treatment of lymphatic vascular diseases could be generated.
Birth Weight, Adult Weight And Podocyte Depletion.
Funder
National Health and Medical Research Council
Funding Amount
$796,252.00
Summary
A major role of our kidneys is to filter our blood. A key cell type in our kidney filters is an octopus-shaped cell known as the podocyte. If we are not born with enough podocytes, or if the filters grow too large after birth due for example to excessive weight gain, the podocytes cannot adequately filter the blood, and this can lead to kidney disease. We will measure podocyte endowment at birth, and assess the effects of weight gain and loss after birth on podocyte features and kidney health.
Solid Oxide Electrolysis Cells with Novel Perovskite-based Cathode. The electrochemical reduction of CO2 and steam to value-added fuels in a high-temperature solid oxide electrolysis cell (SOEC) is practically promising, but technologically challenging. This project aims to develop next generation SOECs using a perovskite-based cathode and scale-up engineering for rapid, bulk production of H2, CO and syngas fuels. Expected outcomes include material engineering, new knowledge on energy conversion ....Solid Oxide Electrolysis Cells with Novel Perovskite-based Cathode. The electrochemical reduction of CO2 and steam to value-added fuels in a high-temperature solid oxide electrolysis cell (SOEC) is practically promising, but technologically challenging. This project aims to develop next generation SOECs using a perovskite-based cathode and scale-up engineering for rapid, bulk production of H2, CO and syngas fuels. Expected outcomes include material engineering, new knowledge on energy conversion technology, and advanced manufacturing technologies. The success of the project will provide a practical solution to reduce fossil CO2 emissions and potential technology for hydrogen production. These will significantly aid Australia in important climate goals and ambitions.Read moreRead less
Priming The Maternal Immune Response To Resist Inflammatory Disorders Of Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$920,972.00
Summary
Preeclampsia and preterm birth are common conditions affecting >15 million pregnancies annually. An underlying cause is the mother’s immune response, which can react adversely to the fetus causing an inflammatory reaction. This project seeks to find ways to strengthen the maternal immune system beginning before conception. The work will provide insights upon which to advise intending parents and will inform development of new treatments options to protect susceptible women.