Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the forma ....Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this is expected to provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.Read moreRead less
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Establishing genetic guidelines for the effective ecological restoration of seagrass meadows. Industry and coastal development in Australia are of national importance for economic growth and prosperity, but they threaten benthic habitats, like seagrasses. Loss of seagrass meadows without mitigation results in greater coastal impacts from damaging storms and waves and a reduction in the health and productivity of marine environments globally. Thus the ecological restoration of seagrass meadows is ....Establishing genetic guidelines for the effective ecological restoration of seagrass meadows. Industry and coastal development in Australia are of national importance for economic growth and prosperity, but they threaten benthic habitats, like seagrasses. Loss of seagrass meadows without mitigation results in greater coastal impacts from damaging storms and waves and a reduction in the health and productivity of marine environments globally. Thus the ecological restoration of seagrass meadows is an urgent national priority action that involves industry, government and the community. Through the detailed assessment of population genetic variation and key population processes in seagrasses, this project will establish genetic guidelines for a more effective seagrass restoration industry.Read moreRead less
Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible ....Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible polymers as a power source and thin film graphene/polymer nanomaterial as an electrode/energy storage media. Second, it aims to design invisible carbon nanotube inks for optical authentication via near infrared activation. Both technologies are expected to thwart sophisticated counterfeits, particularly those supported by organised crime.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Keeping my place in the community: achieving successful ageing-in-place for people with intellectual and developmental disabilities. This project, in partnership with aged care and disability agencies across two states, aims to examine ways the aged care, social and health needs of people with intellectual and developmental disabilities may be met in rural and urban settings. It will explore mechanisms that will lead to a better integration of the aged care and disability sectors.
Vapour phase detection of chemical warfare agents. This project aims to create luminescent plastic optoelectronic materials that can detect airborne chemical warfare agents, particularly nerve agents. Such agents are often odourless and invisible at lethal concentrations, so technology must detect and identify them before exposure. The intended outcomes are design rules for sensitive and selective materials that can be used in a handheld infield detector to sense chemical warfare agents based on ....Vapour phase detection of chemical warfare agents. This project aims to create luminescent plastic optoelectronic materials that can detect airborne chemical warfare agents, particularly nerve agents. Such agents are often odourless and invisible at lethal concentrations, so technology must detect and identify them before exposure. The intended outcomes are design rules for sensitive and selective materials that can be used in a handheld infield detector to sense chemical warfare agents based on the materials’ photophysical properties, and new analytical methods and sensing protocols. This research will be of interest to security agencies in Australia and internationally, and will better protect our military.Read moreRead less
Tailoring nanocomposites with controllable structural-property relationship. This project aims to process and fabricate graphene-based materials into useful devices. Understanding nanocomposite structure-property relationships are crucial to rapidly develop functional devices. This project will use graphene in the form of nanocomposites and precisely construct them in devices via three-dimensional printing. This will be achieved through the polymer chemistry and interfacial engineering of graphe ....Tailoring nanocomposites with controllable structural-property relationship. This project aims to process and fabricate graphene-based materials into useful devices. Understanding nanocomposite structure-property relationships are crucial to rapidly develop functional devices. This project will use graphene in the form of nanocomposites and precisely construct them in devices via three-dimensional printing. This will be achieved through the polymer chemistry and interfacial engineering of graphene for enhanced dispersibility and self-assembly in the targeted polymer matrix, thus affording maximum synergistic properties. The project expects to develop three-dimensional printing techniques and control and understand the effect of micro-patterning and nano-structuring on printed graphene nanocomposites.Read moreRead less