Predicting Renal, Ophthalmic, And Heart Events In The Aboriginal Community – THE PROPHECY Study
Funder
National Health and Medical Research Council
Funding Amount
$2,574,486.00
Summary
Up to 30% of adult Aboriginal people have diabetes yet our knowledge of the causes and predictors of complications remain incomplete. We have established the PROPHECY Study to assess the levels of complications in Aboriginal people with diabetes; to understand the way that these complications occur, and identify what clinical, social and genetic factors could predict who will get those complications to guide clinical management and prevention.
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
MicroRNAs are small molecules that modulate the expression of most genes and so affect nearly every biological process and pathology although, they were only discovered in humans less than 10 years ago. The bottleneck in discovering the functions of miRNAs is in identifying their molecular targets, the majority of which remain unknown. We aim to comprehensively identify direct target genes of epithelial-specific microRNAs and to confirm a number of them by gene target validation approaches.
Novel geometric invariants. Quantum theory is the language of fundamental physics, it describes the small scale structure of matter and possibly space-time. Sophisticated models in condensed matter physics and string theory have exposed geometric and topological structure as basic building blocks of the theory. Issues thrown up by quantum theory are very similar to, and have provided techniques to solve, problems in the geometry of three and four dimensional manifolds. Exciting two way exchanges ....Novel geometric invariants. Quantum theory is the language of fundamental physics, it describes the small scale structure of matter and possibly space-time. Sophisticated models in condensed matter physics and string theory have exposed geometric and topological structure as basic building blocks of the theory. Issues thrown up by quantum theory are very similar to, and have provided techniques to solve, problems in the geometry of three and four dimensional manifolds. Exciting two way exchanges of methods, problems and solutions have emerged. This project aims to settle fundamental questions in the interaction between these two fields.Read moreRead less
Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.
Discovery Early Career Researcher Award - Grant ID: DE220100230
Funder
Australian Research Council
Funding Amount
$365,000.00
Summary
Investigating the Genetic Basis of Human Intrinsic Capacity. Intrinsic capacity is a new concept introduced by experts at the World Health Organisation to promote healthy ageing. It is defined as the composite of an individual’s physical and mental capacities, based on measures of five criteria; cognitive, sensory, locomotor, vitality and psychological. It is a genetically predetermined trait, but is influenced by a range of environmental stimuli. Applying a cutting-edge genetic methodology on b ....Investigating the Genetic Basis of Human Intrinsic Capacity. Intrinsic capacity is a new concept introduced by experts at the World Health Organisation to promote healthy ageing. It is defined as the composite of an individual’s physical and mental capacities, based on measures of five criteria; cognitive, sensory, locomotor, vitality and psychological. It is a genetically predetermined trait, but is influenced by a range of environmental stimuli. Applying a cutting-edge genetic methodology on big biobank datasets, this project aims to examine the role of genetics and the environment to explain the variability of intrinsic capacity between individuals. Understanding the biological basis of intrinsic capacity has major implications for scientific research in healthy ageing and mental wellbeing.Read moreRead less
Special Research Initiatives - Grant ID: SR0354466
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgradu ....Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgraduate training through workshops, summer schools and web based resources and build long-term international collaborations with EU networks and NSERC, NSF and EPSRC institutes as well as bringing together academic and industry leaders.Read moreRead less
New approaches to index theory. The laws of nature are often expressed by differential equations, involving their rates of change. If 'elliptic,' they have an 'index,' which is the number of solutions minus the number of constraints imposed. The Atiyah-Singer index theorem gives a striking calculation of this "index'. An extension is Fractional Index Theory, which has received international attention, having solved a fundamental open problem. A central aim is to investigate this further. I will ....New approaches to index theory. The laws of nature are often expressed by differential equations, involving their rates of change. If 'elliptic,' they have an 'index,' which is the number of solutions minus the number of constraints imposed. The Atiyah-Singer index theorem gives a striking calculation of this "index'. An extension is Fractional Index Theory, which has received international attention, having solved a fundamental open problem. A central aim is to investigate this further. I will assist beginners to navigate to the cutting edge of research through workshops, spring-schools and supervision. Benefits include the enhancement of Australia's position in the forefront of international research.Read moreRead less