Administering Oral Vaccines And Modulating Gastrointestinal Immunity Using A New Physical Device
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Oral vaccination is an ideal delivery route due to its ease of administration, abundance of immune cells in the GI tract and production of protective mucosal immunity at pathogen entry sites. However, its exploitation is limited by delivery challenges such as vaccine degradation in the stomach and poor uptake across mucosa. I will develop a biomedical device which carries and directly delivers vaccines to intestinal mucosa, which ultimately has the potential to replace the needle and syringe.
Reducing The Burden Of Cancer In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$257,561.00
Summary
Chronic kidney disease (CKD) is an important public health problem in Australia and worldwide. Not only does CKD predisposes to end-stage kidney disease, but more importantly, increases the risk of co-morbidities such as cancer and cardiovascular disease, leading to premature death. As an academic nephrologist with interests in clinical epidemiology, health economics and translation research, this proposed program of work will focus on assessing the critical areas in improving the cancer outcome ....Chronic kidney disease (CKD) is an important public health problem in Australia and worldwide. Not only does CKD predisposes to end-stage kidney disease, but more importantly, increases the risk of co-morbidities such as cancer and cardiovascular disease, leading to premature death. As an academic nephrologist with interests in clinical epidemiology, health economics and translation research, this proposed program of work will focus on assessing the critical areas in improving the cancer outcomes in patients with CKD.Read moreRead less
Emu Oil And Protection From Experimentally-induced Ulcerative Colitis And Crohn's Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The inflammatory bowel diseases (IBD), encompassing ulcerative colitis and Crohn’s disease, are chronic intestinal inflammatory disorders of unknown cause. Current treatments for IBD are variably effective highlighting the need for improved therapeutic approaches. Emu Oil is reported to exert potent anti-inflammatory and antioxidant effects. Using well established experimental models, we seek to determine the potential efficacy and underlying mechanism of Emu Oil action in acute and chronic IBD.