Bridging The GAPP Between The Laboratory And Clinic To Prevent Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach (GAPPS).
Funder
National Health and Medical Research Council
Funding Amount
$724,877.00
Summary
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is an inherited form of gastric cancer. Affected patients develop a large number of gastric polyps and are at risk of gastric cancer in their 30s. The only effective treatment is to surgically remove the stomach. Gastrectomy is, however, associated with significant post-operative complications. We will use laboratory and mouse models of GAPPS to identify acceptable new approaches to prevent cancer in these patients.
Use Of Oral Enzymes To Treat Carbohydrate Intolerance: Adjunct Therapy To The Low FODMAP Dietary Treatment Of Irritable Bowel Syndrome.
Funder
National Health and Medical Research Council
Funding Amount
$610,197.00
Summary
Irritable bowel syndrome (IBS) is a common disorder affecting 1 in 7 Australians and fermentation of poorly digested short chain carbohydrates are major dietary triggers. The lack of certain digestive enzymes is a major reason why some carbohydrates are not digested. This project will explore the potential use of oral enzyme supplements to assist with the digestion of these indigestible carbohydrates with the potential for use as adjunct therapy to treat gut symptoms associated with IBS.
Building An Intestine: Manipulating Regeneration Of The Epithelium
Funder
National Health and Medical Research Council
Funding Amount
$609,424.00
Summary
Diseases, infections and pathologies are common clinical problems of the intestinal lining in both infants and adults. Individuals with these conditions can experience nutritional problems and severe cases result in death. The intestinal lining is generated from a small population of stem cells. In this study we use of a mouse model where the stem cells are marked and will examine what factors regulate stem cells in the intestine with the aim of facilitating intestinal tissue regeneration.