Understanding the vesicle release mechanisms that regulate peripheral serotonin levels. The purpose of this project is to understand how serotonin is released into the circulation from specialised cells within the gut. As circulating serotonin controls multiple biological systems within the gut and throughout the body, the outcomes of this project will further understandings of the systems controlling essential bodily functions.
Discovery Early Career Researcher Award - Grant ID: DE120101807
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Fat sensing in the oral cavity and gastrointestinal tract: role in the regulation of gastrointestinal function and energy intake in health and obesity. This project will determine whether a reduced capacity to sense, or taste, the presence of fats in the oral cavity and the gastrointestinal tract diminishes the effects of fat on those aspects of gut function that regulate appetite and suppress energy intake. The project will, accordingly, provide important insights into the pathophysiology of ob ....Fat sensing in the oral cavity and gastrointestinal tract: role in the regulation of gastrointestinal function and energy intake in health and obesity. This project will determine whether a reduced capacity to sense, or taste, the presence of fats in the oral cavity and the gastrointestinal tract diminishes the effects of fat on those aspects of gut function that regulate appetite and suppress energy intake. The project will, accordingly, provide important insights into the pathophysiology of obesity.Read moreRead less
Do pancreatic stellate cells play a role in pancreatic exocrine secretion? 3 major national benefits: 1)Alignment with research priority goals of preventative health care and ageing well ageing productively. Elucidation of mechanisms of action of CCK and the interaction of PSCs and acinar cells in mediating pancreatic secretion will help refine our approach to the prevention and treatment of disorders related to the above processes viz. maldigestion, malabsorption, obesity and pancreatic cancer. ....Do pancreatic stellate cells play a role in pancreatic exocrine secretion? 3 major national benefits: 1)Alignment with research priority goals of preventative health care and ageing well ageing productively. Elucidation of mechanisms of action of CCK and the interaction of PSCs and acinar cells in mediating pancreatic secretion will help refine our approach to the prevention and treatment of disorders related to the above processes viz. maldigestion, malabsorption, obesity and pancreatic cancer. 2)Enhancement of Australia's reputation in gastrointestinal (GI) research through a unique collaboration between internationally recognised researchers in GI and pancreatic biology. 3)Training opportunities for Australian research students and scientists in physiology, gastroenterology and pancreatology.Read moreRead less