Elf5 And The Basis For Antiestrogen Resistant Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,181,326.00
Summary
Resistance to anti estrogen therapies causes half of breast cancer deaths. We have recently discovered (Plos Biol 2012) that the transcription factor Elf5 is intimately involved in this process. This grant will develop our understanding of the transcriptional and genomic events involving Elf5 that lead to antiestrogen resistance and metatstasis, to develop new models of antiestrogen resistance, biomarkers that predict antiestrogen resistance and new therapeutic targets and strategies that preven ....Resistance to anti estrogen therapies causes half of breast cancer deaths. We have recently discovered (Plos Biol 2012) that the transcription factor Elf5 is intimately involved in this process. This grant will develop our understanding of the transcriptional and genomic events involving Elf5 that lead to antiestrogen resistance and metatstasis, to develop new models of antiestrogen resistance, biomarkers that predict antiestrogen resistance and new therapeutic targets and strategies that prevent antiestrogen resistance.Read moreRead less
Novel Epigenetic And Molecular Determinants Of Gastric Cancer Initation And Progression
Funder
National Health and Medical Research Council
Funding Amount
$432,909.00
Summary
Over one million deaths from stomach cancer occur annually. This often fatal disease can be caused by infection with the bacterium H. pylori. I am a molecular biologist seeking to understand how inflammation caused by H. pylori drives a genetic signature which can be used to predict stomach cancer risk. I will also study how a new family of stomach proteins can prevent tumour growth. My research aims to lead new initiatives for early detection and treatment of stomach cancer.