Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase. The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the ....Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase. The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the passage of cells through the cell cycle so that repair can occur. This project studies the mechanism of action of one of these enzymes which will be of benefit in designing new compounds to fight disease. Read moreRead less
The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
Understanding the origin, epidemiology and transmission threat of chlamydial infections between Australian native animals and livestock. Chlamydial infections of koalas and livestock cause diseases of significant economic and environmental concern. Molecular analysis of livestock and native animal strains will improve understanding of the factors associated with transmission of these important pathogens, improving the ability to manage affected Australian animal populations.
The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more ....The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more effective control measures. The project will develop a new paradigm about the roles of stress and immunity in biological invasion, applicable to the control of other invasive species and to understanding processes at work when environmental changes force species to shift their ranges.Read moreRead less
When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localizatio ....When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localization and Mapping (SLAM) algorithms with Partially Observable Markov Decision Processes (POMDP) and Deep Reinforcement learning. This should provide significant benefits, such as more responsive search and rescue inside collapsed buildings or underground mines, as well as fast target detection and mapping under the tree canopy. Read moreRead less
Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space ....Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space launch and global travel times. Expected benefits include reduced cost for access to space and the ability to design and develop advanced aerospace technology.Read moreRead less
Geometric variational problems and nonlinear partial differential systems. We will investigate several important problems on non-linear partial differential systems, bridging analysis, differential geometry and mathematical physics. Harmonic maps are the prototype of maps minimizing the Dirichlet energy. The liquid crystal configuration generalizes the harmonic map with values into two dimensional spheres. The Yang-Mills equations originated from particle physics. We will make fundamental contri ....Geometric variational problems and nonlinear partial differential systems. We will investigate several important problems on non-linear partial differential systems, bridging analysis, differential geometry and mathematical physics. Harmonic maps are the prototype of maps minimizing the Dirichlet energy. The liquid crystal configuration generalizes the harmonic map with values into two dimensional spheres. The Yang-Mills equations originated from particle physics. We will make fundamental contributions to these topics: Regularity problem and energy minimality of weakly harmonic maps, Weak solutions of the liquid crystal equilibrium system, Yang-Mills heat flow and singular Yang-Mills connections.
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The role of behavioural interactions in shaping invasion dynamics: A global synthesis using the common myna as a model system. Invasive species have detrimental effects on human health, the economy and native biodiversity. This study will address a major gap in our scientific understanding of invasions by undertaking the first large-scale examination of the role of interactions between species in determining the dynamics and outcomes of biological invasions. The project will integrate data, acro ....The role of behavioural interactions in shaping invasion dynamics: A global synthesis using the common myna as a model system. Invasive species have detrimental effects on human health, the economy and native biodiversity. This study will address a major gap in our scientific understanding of invasions by undertaking the first large-scale examination of the role of interactions between species in determining the dynamics and outcomes of biological invasions. The project will integrate data, across four continents, on dispersal, demography, breeding and behavioural interactions into one framework to create a cutting-edge model of invasion dynamics, using the highly invasive common myna as a model system. This novel approach will significantly advance theoretical developments in invasion biology and will inform pest management and threat mitigation efforts globally.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this resear ....Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this research will have wide implications and applications in biotechnology, genetic engineering, animal breeding, medical science and advanced informatics.Read moreRead less