Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing ....Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing nonlinear control strategies. The expected outcomes will include new system and control theories, concepts, principles and technologies in controller design that can provide reliable flight control for bio-inspired, flapping-wing systems.Read moreRead less
Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication ....Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication has succeeded. Search Theory has been applied for over 60 years in a wide range of non-biological monitoring problems, resulting in large increases in target detection rates. Gains of a similar magnitude in invasive species detection would greatly enhance Australia's capacity to manage these threats.Read moreRead less
Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory sp ....Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory species, we can generalise for many species, including economic plants. Thus it may be possible to make designer crops through targeted genetic changes to their floral structure.Read moreRead less
Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculptur ....Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculpturing of plant organs by site-specific inhibition of growth is a newly discovered mechanism that may be useful in manipulating plant architecture.Read moreRead less
Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate pos ....Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate possibilities for modifying the patterns of leaf and flower development in agricultural and horticultural species. Crops with larger leaves, or flowers of different structure, may result.Read moreRead less
Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safe ....Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safety view points, that a way be found to ensure reliable and viable operation of complex plants. A first step in achieving this goal is to detect faults on-line and in real-time when they occur and identify their location and characteristics, which is the aim of this project.Read moreRead less
Potential of gene drives to eliminate incursions of Drosophila suzukii. This project aims to test the efficacy and evolutionary stability of different types of gene drives, and model whether gene drives can be used to eliminate incursions of Drosophila suzukii into Australia. It is now possible to use genome editing technology to alter populations of organisms using ‘gene drives’. Multiple strategies have been conceived with a major distinction between those that aim to eliminate populations ver ....Potential of gene drives to eliminate incursions of Drosophila suzukii. This project aims to test the efficacy and evolutionary stability of different types of gene drives, and model whether gene drives can be used to eliminate incursions of Drosophila suzukii into Australia. It is now possible to use genome editing technology to alter populations of organisms using ‘gene drives’. Multiple strategies have been conceived with a major distinction between those that aim to eliminate populations versus those that aim to modify populations. This project will examine these strategies in two fly species, the model, Drosophila melanogaster and the devastating pest of horticulture, Drosophila suzukii. The project expects to assess a gene drive strategy to control the invasive pest that threatens the Australian soft-skinned fruit industries.Read moreRead less
Structured barrier and penalty functions in infinite dimensional optimisation and analysis. Very large scale tightly-constrained optimisation problems are ubiquitous and include water management, traffic flow, and imaging at telescopes and hospitals. Massively parallel computers can solve such problems and provide physically realisable solution only if subtle design issues are mastered. Resolving such issues is the goal of this project.
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.