Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less
A multiscale-multifunctional approach to advanced diagnosis and operator performance in complex process systems. Major process system failures and subsequent poor diagnosis continues to produce significant company disruption, environmental damage, injury and possible loss of life. The benefits of this work will be reduced impacts and risks. This work will provide a new integrated approach with structured tools and diagnostic designs for process industries. It should have direct impacts on compan ....A multiscale-multifunctional approach to advanced diagnosis and operator performance in complex process systems. Major process system failures and subsequent poor diagnosis continues to produce significant company disruption, environmental damage, injury and possible loss of life. The benefits of this work will be reduced impacts and risks. This work will provide a new integrated approach with structured tools and diagnostic designs for process industries. It should have direct impacts on company performance through improved diagnosis, more timely response and hence reduced likelihood of major accidents. It will help to improve overall risk management practice in the process industries with less impact on people, property and environment, thus improving operational performance. Local communities will be direct beneficiaries of these reduced risks.Read moreRead less