Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, re ....Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and bioinformatics; increase global visibility with increased investment in Australian science; improved animal welfare and production via better control of infectious diseases; commercial products with benefits to agricultural producers in regional and rural communities.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Enhanced Analysis and Structural Design of Pavements - Virtual Laboratory for Advanced Pavement Design. The proposed research will lead to improved pavement engineering procedures, which will reduce the maintenance costs for future pavement projects, and will result in cost-effective and more reliable design of new pavements.
Closing the Gap in Pipe Condition Assessment using Hydro-Acoustic Waves. Worldwide, the deterioration of water distribution pipeline infrastructure is driving an unsustainable explosion in maintenance and repair costs. In collaboration with industry leader Detection Services, this project will develop new methods to detect pipe condition faults at a scale and precision not currently possible. The outcome will be an advanced, yet practical, technology that provides critical information on pipe co ....Closing the Gap in Pipe Condition Assessment using Hydro-Acoustic Waves. Worldwide, the deterioration of water distribution pipeline infrastructure is driving an unsustainable explosion in maintenance and repair costs. In collaboration with industry leader Detection Services, this project will develop new methods to detect pipe condition faults at a scale and precision not currently possible. The outcome will be an advanced, yet practical, technology that provides critical information on pipe condition using new innovative active hydro-acoustic signal generators and sensors, combined with state-of-the-art signal analysis methods. The unprecedented cost-effectiveness of the technology will ensure a broad use in the water industry for targeted and efficient action, creating jobs and saving costs.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less
Direct geothermal energy: Reducing the rural industries’ carbon footprint. Direct geothermal energy: Reducing the rural industries’ carbon footprint. This project aims to design poultry brooder houses using geothermal technology. Reducing greenhouse gas emissions is a global priority. The lack of natural gas in rural areas and brooder houses’ heating and cooling needs make geothermal ideal. Direct geothermal systems use shallow ground both as a heat source and as a heat sink for cooling, using h ....Direct geothermal energy: Reducing the rural industries’ carbon footprint. Direct geothermal energy: Reducing the rural industries’ carbon footprint. This project aims to design poultry brooder houses using geothermal technology. Reducing greenhouse gas emissions is a global priority. The lack of natural gas in rural areas and brooder houses’ heating and cooling needs make geothermal ideal. Direct geothermal systems use shallow ground both as a heat source and as a heat sink for cooling, using heat pumps. Their application to poultry brooder houses could reduce electricity consumption by up to 75% and thus greenhouse gas emissions, since 91% of electricity comes from fossil fuels in Australia; minimise the need for expensive bottled gas heating; reduce the levels of ammonia emissions; and increase farm productivity.Read moreRead less
A new approach to structural design that incorporates the effect of non-structural components. The construction industry is a significant contributor to the Australian economy. Each year billions of dollars are spent erecting new high rise buildings. Further, Australian engineering firms bid on major construction projects throughout the world, particularly in Asia and the Middle East. The research described here promises to deliver economies to the Australian construction industry as well as e ....A new approach to structural design that incorporates the effect of non-structural components. The construction industry is a significant contributor to the Australian economy. Each year billions of dollars are spent erecting new high rise buildings. Further, Australian engineering firms bid on major construction projects throughout the world, particularly in Asia and the Middle East. The research described here promises to deliver economies to the Australian construction industry as well as equipping local firms involved in structural design to better compete for offshore work .
Community benefits will take the form of reduced construction costs and the capacity for a more complete and up to date knowledge of the structural performance and risk of aging assets, thereby increasing community confidence and safety.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental ....Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental protection against PFASs and establishment of new approaches for predicting functional containment lifetimes of liner systems. These outcomes are expected to benefit the waste and remediation industries by influencing next-generation design regulations to ensure long-term environmental protection from PFAS.Read moreRead less
Bayesian back analysis for settlement prediction of soft soils. The settlement of road embankments built on soft soils can take many years which has created additional challenges for road design and construction. Despite many years of experience with the Pacific Highway Upgrade, industry partners have seen many examples where embankments have settled more than expected during construction and after road opening. This causes potential delay delivering projects, ponding, potential aquaplaning and ....Bayesian back analysis for settlement prediction of soft soils. The settlement of road embankments built on soft soils can take many years which has created additional challenges for road design and construction. Despite many years of experience with the Pacific Highway Upgrade, industry partners have seen many examples where embankments have settled more than expected during construction and after road opening. This causes potential delay delivering projects, ponding, potential aquaplaning and unexpected maintenance. This project aims at developing useful tools for industry to better predict the settlement of embankment built on soft soils. The intended outcomes can help to increase the safety level of road transportation system of Australia, reduce construction and maintenance costs.Read moreRead less