Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specificat ....Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specifications. This is due to the limited understanding of wind-induced fatigue of cladding. This project will provide the framework for understanding and minimizing cladding fatigue. A realistic single test will also reduce cost and result in better design systems.Read moreRead less
The response of beams subjected to axial load and lateral soil movements. Beams (piles, soil nails, and pipelines) are not only subjected to axial (vertical, axial and longitudinal)loading, but often withstand simultaneous lateral loading, due to either explicit structural loads, or due to loads induced by movement of the soils in which they are founded. Bridge piles adjacent to an approach embankment are one example. This project will provide experimental evidence to assist with the estimation ....The response of beams subjected to axial load and lateral soil movements. Beams (piles, soil nails, and pipelines) are not only subjected to axial (vertical, axial and longitudinal)loading, but often withstand simultaneous lateral loading, due to either explicit structural loads, or due to loads induced by movement of the soils in which they are founded. Bridge piles adjacent to an approach embankment are one example. This project will provide experimental evidence to assist with the estimation of capacity, axial and shear resistance, the validation of unified solutions for beams subjected to simultaneous lateral soil movements and axial loads. Such experimental evidence and analytical solutions are not currently available. The evidence will also assist with solving a contradictory, existing design principle, which will lead to an economic and efficient design approach.Read moreRead less
Harnessing properties of liquid metals for future devices. This project aims to hybridise low toxicity liquid metal alloys of gallium with surface confined functional micro/nano materials and explore fundamental new fluidic and physical-chemistry phenomena. Liquid metals are an under-used group of materials, but their combination of flexibility, bestowed by their room temperature fluidity, and metallic properties means they demonstrate startling behaviour. The expected outcomes are new devices a ....Harnessing properties of liquid metals for future devices. This project aims to hybridise low toxicity liquid metal alloys of gallium with surface confined functional micro/nano materials and explore fundamental new fluidic and physical-chemistry phenomena. Liquid metals are an under-used group of materials, but their combination of flexibility, bestowed by their room temperature fluidity, and metallic properties means they demonstrate startling behaviour. The expected outcomes are new devices and systems such as reconfigurable and highly efficient actuators/generators, catalysts, sensors, and electronic and optical components.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100138
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems ....National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems. The facility may advance understanding of the fundamental behaviour of critical infrastructure exposed to impact loading and will foster innovations in design and construction. Applications may include improvement of the structural safety of infrastructure including railway networks, tunnels and bridges, and also the development of cost-effective and environmentally friendly building and construction materials. Read moreRead less