Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228900
Funder
Australian Research Council
Funding Amount
$603,000.00
Summary
Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and b ....Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and barriers can perform safely when subjected to very heavy traffic and impact loads under laboratory and typical service conditions. This application seeks funds for establishing a unique hi-tech testing facility in Australia vital for advancing such infrastructure technology.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less
Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct applicat ....Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct application in civil engineering as well as in environmental, mining and petroleum engineering which together make up a significant portion of the nation's industry.Read moreRead less