Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of th ....Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of the host-pathogen interactions. A successful outcome could contribute an additional 5-20% increase in crop yields (depending on the crop) through inherent resistance of crops to nematode pests. This would benefit rural communities and the national economy, and could also generate international royalties.Read moreRead less
Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. ....Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. This project will develop new cost-effective methods for designing against rock fall events using a combination of advanced testing and computer modelling.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560987
Funder
Australian Research Council
Funding Amount
$156,697.00
Summary
Robust High Resolution Gene and Protein Expression Analysis Facilities in WA. Biological research is playing an increasingly important role in keeping agriculture internationally competitive and helping to unravel the basic mechanisms underpinning plant and animal health. This collaborative research equipment will greatly enhance and extend our existing functional genomic facilities in WA, allowing robust pre-fractionation of samples for directed proteomic analysis within complex systems and al ....Robust High Resolution Gene and Protein Expression Analysis Facilities in WA. Biological research is playing an increasingly important role in keeping agriculture internationally competitive and helping to unravel the basic mechanisms underpinning plant and animal health. This collaborative research equipment will greatly enhance and extend our existing functional genomic facilities in WA, allowing robust pre-fractionation of samples for directed proteomic analysis within complex systems and allowing accurate and sensitive measurement of gene expression. Both of these are critical for analysis of low abundance components involved in signalling and regulatory functions in biological samples.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453722
Funder
Australian Research Council
Funding Amount
$385,240.00
Summary
Collaborative Genomics, Proteomics and Metabolomics Facility for Western Australia. Plant and animal agriculture in Western Australia contributes $6billion per annum to the nation. Biotechnology is playing an increasingly important role in keeping agriculture internationally competitive, and requires investment in platform technologies to underpin basic and applied research. This collaborative project will provide state-of-the-art equipment and extend existing joint facilities that will enable ....Collaborative Genomics, Proteomics and Metabolomics Facility for Western Australia. Plant and animal agriculture in Western Australia contributes $6billion per annum to the nation. Biotechnology is playing an increasingly important role in keeping agriculture internationally competitive, and requires investment in platform technologies to underpin basic and applied research. This collaborative project will provide state-of-the-art equipment and extend existing joint facilities that will enable WA researchers to carry out high quality research on genomics, proteomics and the metabolic functioning of plants and animals. This will generate new knowledge, provide advanced training and help ensure that Australian R&D in agricultural biotechnology stays at the forefront and benefits the nation.Read moreRead less
Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and ....Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and remediation. Development of accurate predictions is expected to be achieved through physical model testing, numerical modelling and analysis of field data. Predictions should improve subsea reliability and lead to omission of scour protection in some situations, increasing international competitiveness of our offshore oil and gas industry.Read moreRead less
Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties a ....Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties associated with the torque and vertical force required for installation in complex seabeds, and their performance under environmental loading. The project will address these specific points through a combination of physical, numerical and analytical modelling, using data and design scenarios provided by industry.
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