Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100154
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
The Advanced DNA Identification and Forensics Facility. The advanced DNA identification and forensics facility:
The project aims to establish a national integrated facility for cutting-edge forensic genetic research, resources and expertise in wildlife, forest and environmental DNA identification to improve our capacity to identify unknown biological material. The project’s goal will be to enhance synergies between academic research, service delivery and forensic application of DNA identificati ....The Advanced DNA Identification and Forensics Facility. The advanced DNA identification and forensics facility:
The project aims to establish a national integrated facility for cutting-edge forensic genetic research, resources and expertise in wildlife, forest and environmental DNA identification to improve our capacity to identify unknown biological material. The project’s goal will be to enhance synergies between academic research, service delivery and forensic application of DNA identification technologies, addressing vital questions such as: From which individual or species did this material originate? Where in the world is it from? Is it legal? The proposed facility may deliver applied outcomes for government, the criminal justice system, and industry, such as improved pest and threatened species identification; biosecurity, prosecutions of wildlife crime and illegal logging; and missing person and disaster victim identification.Read moreRead less
Generating a targeted mutation resource in zebrafish. How do genes function to build organisms and how are they regulated to produce organs and tissues? Using a new technique to target specific genes in the genome of zebrafish, this project will determine how genes control formation of different tissues. The new gene "knockout" technology will fundamentally change our understanding of how genes work during development.
Genomics of temperature response in plants. Climate change is predicted to have negative impacts on Australian agriculture. This project will use genomic tools to uncover biological mechanisms for plant response to temperature that will help design crop varieties that are more tolerant to higher temperatures.
The role of non-coding RNAs in T cell development. The goal of this project is to discover the genes responsible for the development of a healthy immune system. To achieve this goal, a battery of next generation genomics technologies are being applied for the discovery of new genes and to study their function.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Genome-wide determination of Puccinia psidii s.l. rust resistance in eucalypts. Recently, guava rust was detected in Australia, posing significant risks to native flora, plantations, and timber exports. Scientists from The University of Melbourne and Victorian Department of Primary Industries together with tree breeders, forest growers and forest managers aim to use tree genomics rust resistance breeding to enable management and operational responses and inform policy development.
Alternative splicing in apicomplexan parasites. The project intends to provide a detailed picture of how alternative splicing is regulated in four biologically diverse apicomplexan parasites, and to explain why parasites need this molecular trick to survive. Alternative splicing is an important means by which organisms increase the diversity of proteins encoded by their genome. Although this mechanism is well studied in humans, little is known about the extent of this phenomenon in other organis ....Alternative splicing in apicomplexan parasites. The project intends to provide a detailed picture of how alternative splicing is regulated in four biologically diverse apicomplexan parasites, and to explain why parasites need this molecular trick to survive. Alternative splicing is an important means by which organisms increase the diversity of proteins encoded by their genome. Although this mechanism is well studied in humans, little is known about the extent of this phenomenon in other organisms, nor how the process is regulated. The project plans to test if alternative splicing is required to transition between different life stages, just as alternative splicing is required for tissue differentiation in animals, and describe how alternative splicing contributes to apicomplexan proteome diversity.Read moreRead less