CesA (cellulose synthase) genes of Arabidopsis; all doing the same job or specialists cooperating to make the most abundant biopolymer. The biosphere makes more cellulose than any other polymer with fibre industries depending on its physical properties and atmospheric carbon dioxide levels depending on its stability as a carbon sink. Demonstrations that cellulose production needs CesA genes drove recent progress in elucidating the mechanism of synthesis. CesA proteins all look very similar but i ....CesA (cellulose synthase) genes of Arabidopsis; all doing the same job or specialists cooperating to make the most abundant biopolymer. The biosphere makes more cellulose than any other polymer with fibre industries depending on its physical properties and atmospheric carbon dioxide levels depending on its stability as a carbon sink. Demonstrations that cellulose production needs CesA genes drove recent progress in elucidating the mechanism of synthesis. CesA proteins all look very similar but if all do the same job, why do plants need so many and why do none seem redundant? We will make gene interchanges in transgenic plants, build chimeric genes and identify where each CesA protein operates. This will identify their individual and cooperative contributions to cellulose production.Read moreRead less
Recomputing the canon: using computational methods to develop an alternative understanding of the history of 20th century architecture. Because buildings are designed to last for many generations, and they represent a substantial economic investment, architecture remains one of the most tangible and persistent reflections of a culture's spiritual, social and political values. This is why it is said, to understand architecture is to understand society and its principles. This research develops an ....Recomputing the canon: using computational methods to develop an alternative understanding of the history of 20th century architecture. Because buildings are designed to last for many generations, and they represent a substantial economic investment, architecture remains one of the most tangible and persistent reflections of a culture's spiritual, social and political values. This is why it is said, to understand architecture is to understand society and its principles. This research develops an alternative history of 20th century architecture that will not only allow for a deeper understanding of, and appreciation for, our own constructed heritage, but will also inform the design and production of future buildings which are both socially and culturally responsive.Read moreRead less
Bioeconomic Modelling of Marine Reserves. Australian waters contain a huge range of biodiversity, but are under threat from human activities. To face this challenge and resolve the problems of depleted fisheries and habitat destruction, innovative approaches are required to integrate marine biology with fisheries economics. The research meets this immediate need by developing bioeconomic models of marine reserves to determine reserve location and size, and analyse interactions between reserves a ....Bioeconomic Modelling of Marine Reserves. Australian waters contain a huge range of biodiversity, but are under threat from human activities. To face this challenge and resolve the problems of depleted fisheries and habitat destruction, innovative approaches are required to integrate marine biology with fisheries economics. The research meets this immediate need by developing bioeconomic models of marine reserves to determine reserve location and size, and analyse interactions between reserves and harvested areas under environmental uncertainty. The models will be developed using the latest developments in economics, biology and numerical methods and will be used to conserve Australia's marine biodiversity and improve fisheries management.Read moreRead less
Adaptive economic management of Australia's urban water. This project responds to the so-called 'wicked problem' of ensuring an adequate supply of water to urban consumers at the lowest price even during long-term droughts. The project will generate, for the first time in the world, an integrated, dynamic, and adaptive supply and demand model to manage urban water optimally over time.
Probing the four photosynthetic membrane protein complexes at work in situ in leaves. This proposal aims at sustainable improvements in plant productivity and photosynthetic adaptation in drastic Australian climates. In photosynthesis, membranes with the four multiprotein complexes use sunlight to make compounds that drive carbon assimilation. Instead of the usual dissection of photosynthetic membranes, this project will develop and refine the applicant's rapid, reliable, non-intrusive technique ....Probing the four photosynthetic membrane protein complexes at work in situ in leaves. This proposal aims at sustainable improvements in plant productivity and photosynthetic adaptation in drastic Australian climates. In photosynthesis, membranes with the four multiprotein complexes use sunlight to make compounds that drive carbon assimilation. Instead of the usual dissection of photosynthetic membranes, this project will develop and refine the applicant's rapid, reliable, non-intrusive techniques to probe the four membrane complexes at work in their native state in leaves. Two portable commercial instruments will potentially emerge from the techniques. This novel non-reductionist approach will identify key limitations to photosynthetic performance under stress, and insights into improvements for primary plant productivity.Read moreRead less
Designing Global Sydney: The negotiation of public and private interests. This project links planning policy, urban design and planning history. It assesses the contribution of design-led policy to reconciling private ambitions for economic growth with aspirations for quality public outcomes in the planning approval processes for major commercial development in the Sydney Central Business District (CBD). Concentrating on the past decade, it aims to examine the changing economic structure of the ....Designing Global Sydney: The negotiation of public and private interests. This project links planning policy, urban design and planning history. It assesses the contribution of design-led policy to reconciling private ambitions for economic growth with aspirations for quality public outcomes in the planning approval processes for major commercial development in the Sydney Central Business District (CBD). Concentrating on the past decade, it aims to examine the changing economic structure of the CBD, linking the changing form of the city to evolving design policies. It seeks to recover the experiences of participants in the development approval process and communicate instructive stories of the complex intersection between market forces and design regimens.Read moreRead less
New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these ....New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance. Read moreRead less
The cellulose synthase complex of the Arabidopsis primary cell wall. The polysaccharide cellulose is the basis for the wood and cotton fibre industries of Australia and much of our research on the mechanism of synthesis has been supported by those industries over the past decade. The present project focuses on the proteins making cellulose and how they organised into functional complexes that are able to make cellulose. The knowledge it provides, together with that from other projects, will move ....The cellulose synthase complex of the Arabidopsis primary cell wall. The polysaccharide cellulose is the basis for the wood and cotton fibre industries of Australia and much of our research on the mechanism of synthesis has been supported by those industries over the past decade. The present project focuses on the proteins making cellulose and how they organised into functional complexes that are able to make cellulose. The knowledge it provides, together with that from other projects, will move us towards the situation where we can manipulate the rate at which cellulose is produced and change its detailed properties. This opens the way to industry producing fibres with more desirable properties and producing novel cellulose-based materials tailored to specific applications.Read moreRead less
Functional Genomic Analysis of Exported DNAJ Molecules in the Malaria Parasite Plasmodium falciparum. Malaria is not only a global health problem, but also affects countries surrounding Australia like PNG and Indonesia, reducing the region's stability and prosperity. Environmental changes and increased mobility of people (eg. aid and security personnel) make Australia itself more prone to malaria. The project will translate recent genomic data into functional insights using frontier technology t ....Functional Genomic Analysis of Exported DNAJ Molecules in the Malaria Parasite Plasmodium falciparum. Malaria is not only a global health problem, but also affects countries surrounding Australia like PNG and Indonesia, reducing the region's stability and prosperity. Environmental changes and increased mobility of people (eg. aid and security personnel) make Australia itself more prone to malaria. The project will translate recent genomic data into functional insights using frontier technology to identify new intervention targets for P. falciparum infection. Developing novel targets is mandated by humanity, and also to safeguard Australia's region against the social and economical implication of this disease. An Australian developed intervention would increase the global visibility of its science, leading to increased investments.Read moreRead less
Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evoluti ....Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evolution, paleoclimate change and mineral exploration.Read moreRead less