Campus: Building Modern Australian Universities. This project plans to examine the post-World War Two evolution of the Australian university campus. Modern campuses created opportunities for the realisation of innovative solutions in urban planning, architecture and landscape. The project plans to reveal the physical impacts of political, institutional, social and cultural demands through comparative thematic investigation, digital visualisation and detailed case studies. Foregrounding landscape ....Campus: Building Modern Australian Universities. This project plans to examine the post-World War Two evolution of the Australian university campus. Modern campuses created opportunities for the realisation of innovative solutions in urban planning, architecture and landscape. The project plans to reveal the physical impacts of political, institutional, social and cultural demands through comparative thematic investigation, digital visualisation and detailed case studies. Foregrounding landscape and site, the project aims to establish new historical knowledge, identify campuses as catalysts for urban thinking, and demonstrate strategies for their conservation and adaptation to meet future needs in the tertiary sector.Read moreRead less
Economics of Conserving Australian Tropical Wildlife: An Analysis of the Role of Economic Valuation, Property Rights and Commercialisation. Australian tropical native animals are selected to analyse economic valuation (use and non-use valuation) of wildlife species and to assess systematically the role of property rights and commercialisation in conservation. The project will (1) reduce bias of Australian economic studies in favour of temperate species; (2) answer several unresolved questions ra ....Economics of Conserving Australian Tropical Wildlife: An Analysis of the Role of Economic Valuation, Property Rights and Commercialisation. Australian tropical native animals are selected to analyse economic valuation (use and non-use valuation) of wildlife species and to assess systematically the role of property rights and commercialisation in conservation. The project will (1) reduce bias of Australian economic studies in favour of temperate species; (2) answer several unresolved questions raised in the Parlimentary Report on Commercial Utilisation of Australian Wildlife; (3) advance economic theory (e.g. relating to dynamic influences on economic valuation) and provide new insights into property rights making use of empirical and experimental results, and (4) thereby contribute to public policy decision-making.Read moreRead less
Responding to Climate Change: Australia's Environmental Law and Regulatory Framework. Climate change presents Australia with unparalleled sustainability challenges. Impacts on environmental resources will require an integrated legal and socio-economic regulatory response. An effective and adaptable environmental law framework will be crucial for adaptation and mitigation measures. The project addresses this need by undertaking a comprehensive, interdisciplinary evaluation of Australia's legal ca ....Responding to Climate Change: Australia's Environmental Law and Regulatory Framework. Climate change presents Australia with unparalleled sustainability challenges. Impacts on environmental resources will require an integrated legal and socio-economic regulatory response. An effective and adaptable environmental law framework will be crucial for adaptation and mitigation measures. The project addresses this need by undertaking a comprehensive, interdisciplinary evaluation of Australia's legal capacity to respond to climate change, so identifying appropriate governance structures and regulatory tools. This analysis is vital to positioning Australian environmental law to manage climate change impacts and associated social, ecological and economic costs and to ensure compliance with international obligations.Read moreRead less
Glycointeractions. This project aims to characterise two new classes of structural interactions with carbohydrates: carbohydrate-carbohydrate interactions and short alpha helical domains which can bind carbohydrates. Carbohydrate structures are found on the surface of cells in all forms of life. The intended outcome is to understand the molecular basis for these carbohydrate interactions. This information should provide an intellectual framework for understanding and manipulating these carbohydr ....Glycointeractions. This project aims to characterise two new classes of structural interactions with carbohydrates: carbohydrate-carbohydrate interactions and short alpha helical domains which can bind carbohydrates. Carbohydrate structures are found on the surface of cells in all forms of life. The intended outcome is to understand the molecular basis for these carbohydrate interactions. This information should provide an intellectual framework for understanding and manipulating these carbohydrate interactions, which underpin many processes in biological systems. The findings will inform the design of future drugs to block these interactions and will generate new tools for glycoscience.Read moreRead less
What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dy ....What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dying from viruses; however, it is not known what is cause and effect. This project will clarify Varroa’s exact role in the evolution of virulence in RNA viruses. The intended outcome is increased knowledge allowing the design of an effective treatment to prevent the death of honeybee colonies.Read moreRead less
Control of actin assembly by cell-cell adhesion: molecular effectors and higher order function. Functional cooperation between the actin cytoskeleton and cadherin cell-cell adhesion molecules plays critical roles during development and morphogenesis. This proposal builds on my lab's recent discovery that E-cadherin interacts with and regulates the Arp2/3 actin nucleator complex, a central determinant of actin assembly in cells. We will explore key implications of this finding, concentrating on d ....Control of actin assembly by cell-cell adhesion: molecular effectors and higher order function. Functional cooperation between the actin cytoskeleton and cadherin cell-cell adhesion molecules plays critical roles during development and morphogenesis. This proposal builds on my lab's recent discovery that E-cadherin interacts with and regulates the Arp2/3 actin nucleator complex, a central determinant of actin assembly in cells. We will explore key implications of this finding, concentrating on defining the molecular mechanisms that regulate Arp2/3 and actin assembly in cadherin-based adhesion. Our work combines molecular characterization of regulatory mechanisms and proteomic searches for new regulators, with tests of the higher-order function of this novel process in cell adhesion and recognition.Read moreRead less
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins. This project analyses a fundamental mechanism of how cells work together in tissues. Understanding the fundamental mechanisms of how cells work will provide important basic scientific information to enrich the scientific expertise in Australia and its part in the international community, generate insights relevant for understanding human disease and physical degeneration, and support the training of young scienti ....Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins. This project analyses a fundamental mechanism of how cells work together in tissues. Understanding the fundamental mechanisms of how cells work will provide important basic scientific information to enrich the scientific expertise in Australia and its part in the international community, generate insights relevant for understanding human disease and physical degeneration, and support the training of young scientists in Australia.Read moreRead less
Developing a smart repair technique towards buckling capacity enhancement for imperfect thin-walled structures. This project will contribute significantly to preventing thin-walled structural members with initial defects from abrupt or progressive buckling failure. The advanced technique developed will offer substantial national benefits, such as improved structural reliability and safety, enhanced structural performance and reduced costs in civil engineering.
Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge ma ....Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge may also shed light on the basis of congenital abnormalities and other pathological processes and possibly help us to understand how to prevent or treat these conditions.Read moreRead less
The cultural logic of Queensland architecture: place, taste and economy. The project seeks a better understanding of the cultural role of architecture in Queensland, interrogating notions of place, climate, and art, as they have been used to describe local architecture past and present. This will illuminate the strategies and effects of state support for architecture as a cultural activity and object of taste.